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罕见的腹膜结核模拟腹膜癌病:持续的挑战。

A rare case of peritoneal tuberculosis mimicking peritoneal carcinomatosis: the ongoing challenge.

机构信息

University of California, Riverside School of Medicine, Inland Empire, CA, USA.

Department of Internal Medicine, Kaiser Permanente, 9961 Sierra Ave, Fontana, Inland Empire, CA, 92395, USA.

出版信息

BMC Infect Dis. 2024 Oct 10;24(1):1140. doi: 10.1186/s12879-024-10028-5.

DOI:10.1186/s12879-024-10028-5
PMID:39390402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468269/
Abstract

Tuberculosis (TB) is a serious infection that can involve any organ system and present in various forms. About one-third of the world's population are carriers of latent TB. Although most cases are from a pulmonary origin, there is a rising prevalence of abdominal TB. Patients with pulmonary or extrapulmonary TB are treated similarly through the use of pharmacological therapy. Nonspecific clinical manifestations of TB have made it difficult for clinicians to diagnose. Peritoneal tuberculosis (PTB) is a serious concern as its symptoms overlap with that of many other chronic conditions, especially in those who are immunocompromised. The lack of highly sensitive and specific testing methods has made early intervention difficult, therefore a high index of suspicion is crucial in the progression of the disease. Here, we present a case of a 71-year-old female with a history of abdominal pain, fever, and weakness. Initial investigation with computed tomography (CT) imaging revealed omental fat stranding that pointed towards peritoneal carcinomatosis (PC) from possible recurrence of her ovarian cancer. Further investigation with a peritoneal biopsy was remarkable for caseating granulomas with fat necrosis confirming extrapulmonary TB. This report highlights a rare case of PTB mimicking PC in an elderly patient who is immunocompromised from the use of long-term corticosteroids who continued to decline after pharmacological treatment of the disease.

摘要

肺结核(TB)是一种严重的感染,可以涉及任何器官系统,并以各种形式出现。大约三分之一的世界人口携带潜伏性结核。尽管大多数病例源自肺部,但腹部结核的发病率正在上升。患有肺或肺外结核的患者通过使用药物治疗进行类似的治疗。TB 的非特异性临床表现使得临床医生难以诊断。腹膜结核(PTB)是一个严重的问题,因为其症状与许多其他慢性疾病重叠,尤其是在免疫功能低下的患者中。缺乏高度敏感和特异性的检测方法使得早期干预变得困难,因此在疾病进展过程中保持高度怀疑非常重要。在这里,我们报告了一例 71 岁女性,有腹痛、发热和乏力的病史。最初的计算机断层扫描(CT)成像检查显示网膜脂肪条索状,提示可能是卵巢癌复发导致腹膜癌病(PC)。腹膜活检进一步显示干酪样肉芽肿和脂肪坏死,证实为肺外结核。本报告强调了一例罕见的老年免疫功能低下患者的 PTB 模拟 PC 病例,该患者长期使用皮质类固醇后病情继续恶化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ea/11468269/bbce47ebb412/12879_2024_10028_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ea/11468269/6f292083e531/12879_2024_10028_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ea/11468269/bbce47ebb412/12879_2024_10028_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ea/11468269/6f292083e531/12879_2024_10028_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45ea/11468269/bbce47ebb412/12879_2024_10028_Fig2_HTML.jpg

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Cancers (Basel). 2020 Dec 11;12(12):3730. doi: 10.3390/cancers12123730.
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