脑膜白血病并发B细胞慢性淋巴细胞白血病幼淋巴细胞样转化

Meningeal leukemia complicating prolymphocytoid transformation of B-chronic lymphocytic leukemia.

作者信息

Gobbi M, Tazzari P L, Raspadori D, Cavo M, Pileri S, Tura S

出版信息

Acta Haematol. 1985;74(4):205-7. doi: 10.1159/000206219.

DOI:10.1159/000206219

Abstract

A patient who developed a meningeal leukemia during prolymphocytoid transformation of B-chronic lymphocytic leukemia is described. The central nervous system (CNS) complication occurred after 5 years of relatively benign course. Almost all CNS mononuclear cells showed the typical morphology and immunology of prolymphocytic leukemia cells, whereas a mixture of prolymphocytoid elements and small-sized lymphoid cells was observed in peripheral blood. In this case the more aggressive component was present at diagnosis and showed an uncommonly slow progression allowing the occurrence of the CNS involvement.

摘要

本文描述了一名在B细胞慢性淋巴细胞白血病幼淋巴细胞样转化过程中发生脑膜白血病的患者。中枢神经系统（CNS）并发症发生在相对良性病程的5年后。几乎所有CNS单核细胞均表现出幼淋巴细胞白血病细胞的典型形态和免疫学特征，而外周血中观察到幼淋巴细胞样成分和小淋巴细胞的混合。在这种情况下，侵袭性更强的成分在诊断时就已存在，且进展异常缓慢，从而导致了CNS受累。