基于靶向PI3K/AKT/mTOR信号通路的天然化合物的抗癌药物发现

Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.

作者信息

da Silva Manuele Figueiredo, Lins Arestides Alves, Gomes Midiane Correia, Marinho Washley Phyama de Jesus, de Araújo Rodrigo Santos Aquino, de Moura Ricardo Olimpio, Zhan Peng, Nascimento Igor José Dos Santos, da Silva-Júnior Edeildo Ferreira

机构信息

Research Group of Biological and Molecular Chemistry, Federal University of Alagoas, A.C. Simões campus, Institute of Chemistry and Biotechnology, Maceió, 57072-970, Brazil.

Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.

出版信息

Curr Med Chem. 2024 Oct 10. doi: 10.2174/0109298673325229240928040758.

DOI:10.2174/0109298673325229240928040758

PMID:39390838

Abstract

The term cancer is used to describe a complex pathology characterized by the uncontrollable proliferation of cells, which displays a fast metastatic spread, being a disease with difficult treatment. In this context, Phosphatidylinositol 3-kinase (PI3K) represents a promising pathway to be inhibited, aiming to develop anticancer agents, since it performs a pivotal role in regulating essential cellular processes, including cell proliferation, growth, autophagy, and apoptosis. In parallel, natural compounds can effectively represent a therapeutic strategy to fight against malignant cells. Then, compounds derived from various plant sources, such as flavonoids, terpenoids, alkaloids, coumarins, and lignans, have exhibited remarkable in vitro and in vivo anticancer properties. This review focused in the exploration of natural products targeting the PI3K/AKT/m-TOR signaling pathway, demonstrating that these compounds could even further investigated to reveal novel and effective anticancer drugs in the future.

摘要

“癌症”一词用于描述一种复杂的病理状态，其特征是细胞不受控制地增殖，并呈现快速转移扩散，是一种难以治疗的疾病。在这种情况下，磷脂酰肌醇3激酶（PI3K）是一个有望被抑制的途径，旨在开发抗癌药物，因为它在调节包括细胞增殖、生长、自噬和凋亡在内的基本细胞过程中发挥着关键作用。同时，天然化合物可以有效地成为对抗恶性细胞的治疗策略。然后，来自各种植物来源的化合物，如黄酮类、萜类、生物碱、香豆素和木脂素，已在体外和体内表现出显著的抗癌特性。本综述着重探索靶向PI3K/AKT/m-TOR信号通路的天然产物，表明这些化合物未来甚至可以进一步研究以揭示新型有效的抗癌药物。