Assistant Professor, Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India, Corresponding Author.
Senior Resident, Department of Microbiology, All India Institute of Medical Sciences, Patna, Bihar, India.
J Assoc Physicians India. 2024 Oct;72(10):e28-e30. doi: 10.59556/japi.72.0708.
Plasma cell invasion of the kidney in plasma cell dyscrasia is rare. We are reporting a case of plasma cell infiltration in the kidney presenting as rapidly progressing renal failure. The patient presented with generalized weakness, anemia, and advanced renal failure. The kidney biopsy revealed multifocal atypical CD138-positive plasma cell-rich interstitial inflammation and severe acute tubular injury. In the present situation of clinically unexplained renal failure with suspicion of plasma cell dyscrasia, a kidney biopsy proved to be key to the diagnosis. Hence, malignant plasma cell infiltration in the kidney could indicate underlying plasma cell dyscrasia and may serve as a future myeloma defining event (MDE).
浆细胞异常增生导致的肾脏浆细胞浸润较为少见。我们报告了一例肾脏浆细胞浸润导致的进行性肾衰竭病例。该患者表现为全身乏力、贫血和晚期肾衰竭。肾活检显示多发性局灶性非典型 CD138 阳性浆细胞丰富的间质炎症和严重的急性肾小管损伤。在目前临床原因不明的肾衰竭伴有浆细胞异常增生的情况下，肾活检被证明是诊断的关键。因此，肾脏恶性浆细胞浸润可能提示潜在的浆细胞异常增生，并可能成为未来多发性骨髓瘤的确定事件（MDE）。
