Carlsson R, Dohlsten M, Sjögren H O
Cell Immunol. 1985 Nov;96(1):104-12. doi: 10.1016/0008-8749(85)90343-0.
Histamine inhibited the production of interferon-gamma and interleukin 2 (IL-2) induced in human peripheral blood mononuclear cells by Staphylococcal Enterotoxin A (SEA) but had no effect on the expression of IL-2 receptors. The effects on lymphokine production were dose dependent with maximal inhibition occurring at histamine concentrations of 10(-4) to 10(-6) M. The H2-agonist 4-methylhistamine but not the H1-agonist 2-methylhistamine modulated lymphokine production in a similar manner as histamine. Histamine at concentrations of 10(-3) to 10(-8) M had no inhibitory effect directly on the activity of admixed IL-2 containing medium. The inhibitory effects of histamine could be reversed by the H2-antagonist cimetidine but not by the H1-antagonist diphenhydramine. This indicates that the inhibitory effects of histamine on lymphokine production are mediated through H2-receptors on mononuclear cells.
组胺抑制了金黄色葡萄球菌肠毒素A（SEA）诱导人外周血单个核细胞产生的γ-干扰素和白细胞介素2（IL-2），但对IL-2受体的表达没有影响。对淋巴因子产生的影响呈剂量依赖性，在组胺浓度为10⁻⁴至10⁻⁶ M时出现最大抑制作用。H2激动剂4-甲基组胺而非H1激动剂2-甲基组胺以与组胺相似的方式调节淋巴因子的产生。浓度为10⁻³至10⁻⁸ M的组胺对混合含IL-2培养基的活性没有直接抑制作用。组胺的抑制作用可被H2拮抗剂西咪替丁逆转，但不能被H1拮抗剂苯海拉明逆转。这表明组胺对淋巴因子产生的抑制作用是通过单核细胞上的H2受体介导的。
