Matsuda A, Kuzuya T
Diabetes Res Clin Pract. 1985 Aug;1(2):65-72. doi: 10.1016/s0168-8227(85)80030-9.
Urine C-peptide per 24 h urine (UCPR) was assayed and correlated with the degree of insulin dependence in 324 diabetic patients. The UCPR and UCPR/weight were 74.7 +/- 26.3 micrograms/day and 1.27 +/- 0.36 micrograms/day, kg in healthy subjects, and these values were similar in diet- and sulfonylurea-treated patients. Insulin-dependent diabetics (IDDM) with history of ketosis or ketoacidosis and/or unstable plasma glucose, and patients refractory to sulfonylureas had lower UCPR values (8.5 +/- 6.6 and 22.3 +/- 14.6 micrograms/day) than the other insulin-treated patients (45.4 +/- 30.7 micrograms/day). In more than 90% of diet- and sulfonylurea-treated patients, UCPR exceeded 30 micrograms/day and UCPR/wt. exceeded 0.6 micrograms/day, kg. UCPR was less than 20 micrograms/day and UCPR/wt. less than 0.4 microgram/day,kg in more than 90% of IDDM patients, and less than 40 micrograms/day and 0.8 microgram/day,kg respectively in 80% of sulfonylurea-refractory patients. IDDM patients with more than 20 U/day of insulin doses had lower UCPR values. Longer duration of diabetes was associated with lower UCPR in IDDM patients. The results indicate that UCPR more than 30 micrograms/day or UCPR/wt. more than 0.6 micrograms/day,kg suggest non-insulin dependence, and UCPR less than 20 micrograms/day or UCPR/wt. less than 0.4 micrograms/day,kg suggest insulin dependence. Assay of UCPR provides a simple, non-invasive test for evaluating the degree of insulin dependence in diabetic patients.
对324例糖尿病患者测定了每24小时尿C肽（UCPR），并将其与胰岛素依赖程度进行关联分析。健康受试者的UCPR及UCPR/体重分别为74.7±26.3微克/天和1.27±0.36微克/天·千克，饮食控制和磺脲类药物治疗的患者中这些值与之相似。有酮症或酮症酸中毒病史和/或血糖不稳定的胰岛素依赖型糖尿病（IDDM）患者，以及对磺脲类药物难治的患者，其UCPR值（8.5±6.6和22.3±14.6微克/天）低于其他胰岛素治疗患者（45.4±30.7微克/天）。在超过90%的饮食控制和磺脲类药物治疗的患者中，UCPR超过30微克/天，UCPR/体重超过0.6微克/天·千克。超过90%的IDDM患者UCPR低于20微克/天，UCPR/体重低于0.4微克/天·千克，80%的磺脲类药物难治患者UCPR分别低于40微克/天和0.8微克/天·千克。胰岛素剂量超过20U/天的IDDM患者UCPR值较低。糖尿病病程较长的IDDM患者UCPR较低。结果表明，UCPR超过30微克/天或UCPR/体重超过0.6微克/天·千克提示非胰岛素依赖，UCPR低于20微克/天或UCPR/体重低于0.4微克/天·千克提示胰岛素依赖。UCPR测定为评估糖尿病患者的胰岛素依赖程度提供了一种简单、无创的检测方法。
