Zhu Qiaolin, Huo Yujia, Lin Wenjing, Sun Qianqian, Yan Wentao
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Heliyon. 2024 Sep 26;10(19):e38480. doi: 10.1016/j.heliyon.2024.e38480. eCollection 2024 Oct 15.
This study aimed to analyze ocular characteristics in patients diagnosed with spherophakia, establish effective diagnostic criteria, and aid clinicians in prompt identification and management.
A retrospective case series identified spherophakia cases through medical records and literature searches. The case group included spherophakia patients, and the control group comprised individuals with similar eye conditions. Intraocular lens calculations used the SRK-T formula, and statistical analyses were performed using SPSS. Diagnostic efficacy was assessed through receiver operating characteristic (ROC) curve analysis.
The study included 12 cases (23 eyes) from medical records and 86 patients (142 eyes) from literature sources. Characteristics of spherophakia included bilateral involvement, younger age, shallow anterior chamber depth, lens dislocation, and secondary glaucoma. A diagnostic criterion based on lens power demonstrated high sensitivity (94.3 %) and specificity (91.9 %). ROC analysis yielded area under the ROC curve (AUROC) values of 0.974 for lens power, outperforming refractive error (0.119), corneal curvature (0.465) and axial length (0.496). The lens power cutoff for diagnosing spherophakia was 31.25D.
The study offers crucial insights into spherophakia's clinical characteristics and presents a practical diagnostic criterion using lens power, enhancing early detection and management. Further research is needed to validate and refine these findings, establishing standardized diagnostic criteria for spherophakia.
本研究旨在分析诊断为球形晶状体患者的眼部特征，建立有效的诊断标准，并帮助临床医生进行快速识别和管理。
通过病历和文献检索确定球形晶状体病例的回顾性病例系列。病例组包括球形晶状体患者，对照组由眼部情况相似的个体组成。人工晶状体计算使用SRK-T公式，并使用SPSS进行统计分析。通过受试者操作特征（ROC）曲线分析评估诊断效能。
该研究纳入了病历中的12例（23只眼）以及文献来源的86例患者（142只眼）。球形晶状体的特征包括双侧受累、年龄较轻、前房深度浅、晶状体脱位和继发性青光眼。基于晶状体屈光度的诊断标准显示出高敏感性（94.3%）和特异性（91.9%）。ROC分析得出晶状体屈光度的ROC曲线下面积（AUROC）值为0.974，优于屈光不正（0.119）、角膜曲率（0.465）和眼轴长度（0.496）。诊断球形晶状体的晶状体屈光度截断值为31.25D。
该研究为球形晶状体的临床特征提供了关键见解，并提出了使用晶状体屈光度的实用诊断标准，加强了早期检测和管理。需要进一步研究来验证和完善这些发现，建立球形晶状体的标准化诊断标准。
