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Striking intraneuronal neurofilament inclusions restricted to the locus coeruleus in a patient with Creutzfeldt-Jakob disease.

作者信息

Leitner Felix, Klotz Sigrid, Ornig Karoline, Weis Serge, Gelpi Ellen

机构信息

Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.

Austrian Reference Center for Human Prion Diseases (OERPE).

出版信息

Free Neuropathol. 2024 Oct 2;5:22. doi: 10.17879/freeneuropathology-2024-5721. eCollection 2024 Jan.

DOI:10.17879/freeneuropathology-2024-5721
PMID:39391597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11466044/
Abstract
摘要

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1
Striking intraneuronal neurofilament inclusions restricted to the locus coeruleus in a patient with Creutzfeldt-Jakob disease.一名克雅氏病患者中，显著的神经元内神经丝包涵体局限于蓝斑。
Free Neuropathol. 2024 Oct 2;5:22. doi: 10.17879/freeneuropathology-2024-5721. eCollection 2024 Jan.
2
Heterogeneic autoantibody against neurofilament protein in the sera of animals with experimental kuru and Creutzfeldt-Jakob disease and natural scrapie infection.患有实验性库鲁病、克雅氏病以及自然感染羊瘙痒病的动物血清中针对神经丝蛋白的异种自身抗体。
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3
Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions.患有新型神经丝蛋白病的患者：伴有神经丝蛋白包涵体的痴呆症。
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4
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.明确克雅氏病中的“临床前”MSA。
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5
Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease.疑似散发性克雅氏病中的脑脊液神经丝轻链蛋白
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6
The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.200 kDa和150 kDa的神经丝蛋白与患库鲁病或克雅氏病的黑猩猩的IgG自身抗体发生反应；一种62 kDa的神经丝相关蛋白与患自然痒病的绵羊的血清发生反应。
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Panencephalopathic type of Creutzfeldt-Jakob disease with neuropathologic features similar to Pick's disease.具有与匹克氏病相似神经病理学特征的克雅氏病全脑病变型。
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Intracellular spiral inclusions in cerebral cell processes in Creutzfeldt-Jakob disease.
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10
Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression.神经丝轻链和 tau 浓度在散发性克雅氏病患者的血清中显著增加，tau 与疾病进展速度相关。
J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):955-961. doi: 10.1136/jnnp-2017-317793. Epub 2018 Feb 27.

本文引用的文献

1
The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease.朊病毒病的 Braak 假说，重点是克雅氏病。
Neuropathology. 2020 Oct;40(5):436-449. doi: 10.1111/neup.12654. Epub 2020 May 3.
2
The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins.AD/PART 共病特征提示 CJD 存在独立的发病机制，且错误折叠的 Aβ 和朊病毒蛋白之间不存在交叉播种。
Acta Neuropathol Commun. 2019 Apr 8;7(1):53. doi: 10.1186/s40478-019-0706-6.
3
REM sleep behaviour disorder.快速眼动睡眠行为障碍。
Nat Rev Dis Primers. 2018 Aug 30;4(1):19. doi: 10.1038/s41572-018-0016-5.
4
Locus coeruleus.蓝斑。
Cell Tissue Res. 2018 Jul;373(1):221-232. doi: 10.1007/s00441-017-2649-1. Epub 2017 Jul 7.
5
Clinicopathological Correlations and Concomitant Pathologies in Rapidly Progressive Dementia: A Brain Bank Series.快速进展性痴呆的临床病理相关性及伴发疾病：脑库系列研究
Neurodegener Dis. 2015;15(6):350-60. doi: 10.1159/000439251. Epub 2015 Oct 31.
6
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.铁、多巴胺和神经黑色素途径在脑衰老和帕金森病中的相互作用。
Prog Neurobiol. 2017 Aug;155:96-119. doi: 10.1016/j.pneurobio.2015.09.012. Epub 2015 Oct 9.
7
Identification of clinical target areas in the brainstem of prion-infected mice.朊病毒感染小鼠脑干中临床靶区的鉴定
Neuropathol Appl Neurobiol. 2015 Aug;41(5):613-30. doi: 10.1111/nan.12189. Epub 2015 Apr 23.
8
Coexistence of mixed phenotype Creutzfeldt-Jakob disease, Lewy body disease and argyrophilic grain disease plus histological features of possible Alzheimer's disease: a multi-protein disorder in an autopsy case.混合型克雅氏病、路易体病和嗜银颗粒病并存以及可能的阿尔茨海默病的组织学特征：一例尸检病例中的多蛋白紊乱
Neuropathology. 2015 Feb;35(1):56-63. doi: 10.1111/neup.12150. Epub 2014 Sep 3.
9
Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients.特发性快速眼动睡眠行为障碍中的神经退行性疾病风险：174例患者的研究
PLoS One. 2014 Feb 26;9(2):e89741. doi: 10.1371/journal.pone.0089741. eCollection 2014.
10
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series.在老年人的大脑中，非阿尔茨海默病的神经退行性病变及其组合比人们通常认为的更为常见：一项基于社区的尸检系列研究。
Acta Neuropathol. 2013 Sep;126(3):365-84. doi: 10.1007/s00401-013-1157-y. Epub 2013 Jul 31.