Striking intraneuronal neurofilament inclusions restricted to the locus coeruleus in a patient with Creutzfeldt-Jakob disease.
作者信息
Leitner Felix, Klotz Sigrid, Ornig Karoline, Weis Serge, Gelpi Ellen
机构信息
Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.
Austrian Reference Center for Human Prion Diseases (OERPE).
出版信息
Free Neuropathol. 2024 Oct 2;5:22. doi: 10.17879/freeneuropathology-2024-5721. eCollection 2024 Jan.
Abstract
摘要
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Striking intraneuronal neurofilament inclusions restricted to the locus coeruleus in a patient with Creutzfeldt-Jakob disease.一名克雅氏病患者中，显著的神经元内神经丝包涵体局限于蓝斑。
Free Neuropathol. 2024 Oct 2;5:22. doi: 10.17879/freeneuropathology-2024-5721. eCollection 2024 Jan.
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The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.200 kDa和150 kDa的神经丝蛋白与患库鲁病或克雅氏病的黑猩猩的IgG自身抗体发生反应；一种62 kDa的神经丝相关蛋白与患自然痒病的绵羊的血清发生反应。
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Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression.神经丝轻链和 tau 浓度在散发性克雅氏病患者的血清中显著增加，tau 与疾病进展速度相关。
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Acta Neuropathol. 2013 Sep;126(3):365-84. doi: 10.1007/s00401-013-1157-y. Epub 2013 Jul 31.
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