Aljabab Saif, Mohaimeed Amna, AlMomen Firas, AlSwailem Abdullah, Alayed Yasir
Radiation Oncology Unit College of Medicine King Saud University, Riyadh, Saudi Arabia.
Oncology Center King Saud University Medical City, Riyadh, Saudi Arabia.
Case Rep Oncol Med. 2024 Oct 3;2024:9340657. doi: 10.1155/2024/9340657. eCollection 2024.
Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely.
鼻窦恶性肿瘤（SNMs）是罕见的异质性恶性肿瘤，常表现为局部晚期疾病。当疾病被认为广泛且无法切除时，预后很差。在这种情况下，通常需要高剂量姑息性放疗方案，但理想的剂量和分割方式尚未确定。我们详细介绍一名33岁男性，他最初表现为右侧脸颊上逐渐增大的肿块。病变活检显示为鳞状细胞癌（SCC）。影像学检查显示疾病非常晚期且无法切除，累及多个头颈部亚部位。他在接受外院诱导化疗后病情进一步进展。患者要求迅速控制肿瘤和症状以便回国。我们为他提供了高剂量分程姑息性放疗，采用四次照射，每次14.80 Gy，分四次，每天两次，随后每隔一天分五次给予30 Gy，间隔2周。治疗取得了出色的临床反应，短期内症状缓解，患者能够安全回国。
