Choi Hayoung, Min Kyung Hoon, Lee Young Seok, Chang Youjin, Lee Bo Young, Oh Jee Youn, Baek Ae-Rin, Lee Jongmin, Jeon Kyeongman
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Tuberc Respir Dis (Seoul). 2025 Jan;88(1):69-89. doi: 10.4046/trd.2024.0135. Epub 2024 Oct 11.
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are correlated with high morbidity and mortality rates. Guidelines that consider local epidemiologic data are fundamental for identifying optimal treatment strategies. However, Korea has no HAP/VAP guidelines. This study was conducted by a committee of nine experts from the Korean Academy of Tuberculosis and Respiratory Diseases Respiratory Infection Study Group using the results of Korean HAP/VAP epidemiologic studies. Eleven key questions for HAP/VAP diagnosis and treatment were addressed. The Convergence of Opinion on Suggestions and Evidence (CORE) process was used to derive suggestions, and evidence levels and recommendation grades were in accordance with the Grading of Recommendations Assessment Development and Evaluation (GRADE) methodology. Suggestions were made for the 11 key questions pertinent to diagnosis, biomarkers, antibiotics, and treatment strategies for adult patients with HAP/VAP. Using the CORE process and GRADE methodology, the committee generated a series of recommendations for HAP/VAP diagnosis and treatment in the Korean context.
医院获得性肺炎（HAP）和呼吸机相关性肺炎（VAP）与高发病率和死亡率相关。考虑当地流行病学数据的指南对于确定最佳治疗策略至关重要。然而，韩国尚无HAP/VAP指南。本研究由韩国结核病和呼吸疾病学会呼吸感染研究组的九位专家组成的委员会开展，采用了韩国HAP/VAP流行病学研究的结果。探讨了HAP/VAP诊断和治疗的11个关键问题。采用意见与证据融合（CORE）流程得出建议，证据水平和推荐等级符合推荐分级评估、制定与评价（GRADE）方法。针对成年HAP/VAP患者诊断、生物标志物、抗生素及治疗策略相关的11个关键问题提出了建议。该委员会采用CORE流程和GRADE方法，针对韩国国情制定了一系列HAP/VAP诊断和治疗的建议。
