Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.
Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Nano Lett. 2024 Oct 30;24(43):13825-13833. doi: 10.1021/acs.nanolett.4c04375. Epub 2024 Oct 11.
Chemodynamic therapy (CDT) is an innovative and burgeoning strategy that utilizes Fenton-Fenton-like chemistry and specific microenvironments to produce highly toxic hydroxyl radicals (OH), with numerous methods emerging to refine this approach. Herein, we report a coordination compound, Fe-norepinephrine nanoparticles (Fe-NE NPs), via a one-pot synthesis. The Fe-NE NPs are based on ferrous ions (Fe) and norepinephrine, which are capable of efficient Fe/Fe delivery. Once internalized by tumor cells, the released Fe/Fe exerts the Fenton reaction to specifically produce toxic OH. Moreover, the internal photothermal conversion ability of Fe-NE NPs allows us to simultaneously introduce light to trigger local heat generation and then largely improve the Fenton reaction efficiency, which enables a synergetic photothermal and chemodynamic therapy to realize satisfactory antitumor efficiency. This proof-of-concept work offers a promising approach to developing nanomaterials and refining strategies for enhanced CDT against tumors.
化学动力学治疗（CDT）是一种创新且新兴的策略，利用芬顿-芬顿类似化学和特定的微环境来产生高毒性的羟基自由基（OH），出现了许多方法来改进这种方法。在此，我们通过一锅合成法报告了一种配位化合物，即去甲肾上腺素纳米粒子（Fe-NE NPs）。Fe-NE NPs 基于二价铁离子（Fe）和去甲肾上腺素，能够实现高效的 Fe/Fe 传递。一旦被肿瘤细胞内化，释放的 Fe/Fe 就会发挥芬顿反应，专门产生有毒的 OH。此外，Fe-NE NPs 的内部光热转换能力使我们能够同时引入光来触发局部热产生，从而大大提高芬顿反应效率，实现协同光热和化学动力学治疗，实现令人满意的抗肿瘤效率。这项概念验证工作为开发纳米材料和改进针对肿瘤的增强 CDT 策略提供了一种很有前途的方法。
