Faculty of Sports, German University of Health and Sports, Vulkanstraße 1, 10367, Berlin, Germany.
Support Care Cancer. 2024 Oct 11;32(11):721. doi: 10.1007/s00520-024-08925-1.
The effects of aerobic exercise interventions for reducing fatigue after cancer treatment are well-established, and the effect of resistance training remains uncertain. Therefore, this systematic review and meta-analysis aim to analyze the effect of resistance training and combined resistance and endurance training on cancer-related fatigue (CRF) in breast cancer patients.
A systematic search for randomized controlled trials (RCTs) was conducted on the PubMed, SPORTDiscus, Embase, and Cochrane databases, focusing on the effect of supervised resistance training and combined supervised resistance and endurance training on CRF. Random-effect models were employed for calculating the standardized mean difference (SMD). Risk of bias was assessed with risk of bias 2 (RoB2), and certainty of evidence was judged according to the GRADE approach.
A total of 9 RCTs with 1512 participants were included, and data from 866 participants in 8 RCTs were used for the meta-analysis. The risk of bias was deemed low in seven studies, while one study exhibited attrition bias, and one showed possible selection bias. Resistance training probably reduce the total fatigue (SMD= -0.30, 95% CI -0.52, -0.08, p=0.008), with individual studies showing small effects on physical and emotional CRF. A combined resistance and endurance training reduce total fatigue (SMD= -0.34, 95% CI -0.51, -0.17, p= 0.0001), with individual studies indicating moderate effects on physical fatigue, in daily life fatigue, and small effects on emotional and cognitive CRF.
Both supervised resistance training and combined resistance and endurance training have a small effect on total CRF. There is a trend towards an influence of intensity, with higher intensity potentially resulting in lower total CRF.
有氧运动干预减轻癌症治疗后疲劳的效果已得到充分证实，而抗阻训练的效果仍不确定。因此，本系统评价和荟萃分析旨在分析抗阻训练和抗阻与耐力联合训练对乳腺癌患者癌因性疲劳（CRF）的影响。
在 PubMed、SPORTDiscus、Embase 和 Cochrane 数据库中进行了系统的随机对照试验（RCT）检索，重点关注监督抗阻训练和联合监督抗阻与耐力训练对 CRF 的影响。采用标准化均数差（SMD）计算随机效应模型。采用风险偏倚 2（RoB2）评估风险偏倚，并根据 GRADE 方法判断证据确定性。
共纳入 9 项 RCT，共 1512 名参与者，其中 8 项 RCT 的 866 名参与者的数据用于荟萃分析。7 项研究的风险偏倚被认为较低，1 项研究存在损耗偏倚，1 项研究存在可能的选择偏倚。抗阻训练可能会降低总疲劳（SMD=-0.30，95%CI-0.52，-0.08，p=0.008），个别研究显示对身体和情绪 CRF 有较小的影响。抗阻与耐力联合训练降低总疲劳（SMD=-0.34，95%CI-0.51，-0.17，p=0.0001），个别研究显示对身体疲劳、日常生活疲劳有中等影响，对情绪和认知 CRF 有较小影响。
监督抗阻训练和抗阻与耐力联合训练均对总 CRF 有较小的影响。强度可能有影响的趋势，较高的强度可能会导致总 CRF 降低。
