Chen Xudong, Shi Xuyuan, Yu Zhiruo, Ma Xuelei
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Cancer Med. 2023 Sep;12(17):17692-17705. doi: 10.1002/cam4.6387. Epub 2023 Aug 17.
Women with breast cancer and improved survival often experience treatment-related impairments. High-intensity interval training (HIIT) has emerged as a promising exercise therapy modality for adult cancer patients. However, the overall effects of HIIT in breast cancer patients remain scarce and controversial. Therefore, we conducted a systematic review and meta-analysis to comprehensively evaluate the impact of HIIT on health-related outcomes in breast cancer patients.
We searched the PubMed, Embase, and Web of Science from inception to November 7, 2022. Eligible studies included randomized controlled trials that compared HIIT interventions with usual care (UC) or MICT in breast cancer patients. The primary outcome assessed was physical fitness, and exploratory outcomes included body composition, blood-borne biomarkers, and patient-reported outcomes. Summary data were extracted, and standardized mean differences (SMD) were calculated for meta-analysis. For outcomes that could not be pooled, a systematic review was conducted.
Our analysis included 19 articles from 10 studies, encompassing 532 participants who met the inclusion criteria. Pooled results demonstrated that HIIT was superior to UC in improving peak oxygen uptake (VO ). The SMD for VO (L/min) and VO (mL/kg/min) was 0.79 (95% CI 0.13, 1.45) and 0.59 (95% CI 0.01, 1.16), respectively. No significant differences in VO were found between the HIIT and MICT groups. Meta-analyses on body composition and blood-borne biomarkers showed no significant differences between HIIT and UC. Systematic review indicated favorable effects of HIIT on muscle strength, fatigue, and emotional well-being.
HIIT is a time-efficient alternative to MICT for improving VO and may also enhance muscle strength and alleviate fatigue and emotional symptoms in breast cancer patients. HIIT should be considered as an important component of exercise prescription in breast cancer care. Further studies with larger cohorts are needed to determine the clinical significance of HIIT-induced changes in terms of other outcomes in women with breast cancer.
乳腺癌患者生存率提高，但常伴有与治疗相关的功能障碍。高强度间歇训练（HIIT）已成为一种有前景的成年癌症患者运动治疗方式。然而，HIIT对乳腺癌患者的总体影响仍缺乏且存在争议。因此，我们进行了一项系统评价和荟萃分析，以全面评估HIIT对乳腺癌患者健康相关结局的影响。
我们检索了从创刊至2022年11月7日的PubMed、Embase和Web of Science数据库。符合条件的研究包括比较HIIT干预与常规护理（UC）或中等强度持续训练（MICT）对乳腺癌患者影响的随机对照试验。评估的主要结局是体能，探索性结局包括身体成分、血液生物标志物和患者报告的结局。提取汇总数据，并计算标准化均值差（SMD）用于荟萃分析。对于无法合并的结局，进行了系统评价。
我们的分析纳入了来自10项研究的19篇文章，涵盖532名符合纳入标准的参与者。汇总结果表明，HIIT在改善峰值摄氧量（VO）方面优于UC。VO（L/min）和VO（mL/kg/min）的SMD分别为0.79（95%CI 0.13，1.45）和0.59（95%CI 0.01，1.16）。HIIT组和MICT组之间在VO方面未发现显著差异。对身体成分和血液生物标志物的荟萃分析显示，HIIT和UC之间无显著差异。系统评价表明，HIIT对肌肉力量、疲劳和情绪健康有积极影响。
HIIT是一种提高VO的高效替代MICT的方法，还可能增强乳腺癌患者的肌肉力量，减轻疲劳和情绪症状。HIIT应被视为乳腺癌护理运动处方的重要组成部分。需要进一步开展更大样本量的研究，以确定HIIT引起的变化对乳腺癌女性其他结局的临床意义。
