Graham Carolyn T, Gordon Siamon, Kubes Paul
Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, 259 Wenhua 1st Road Guishan Dist., Taoyuan, Taiwan.
Cell Tissue Res. 2025 May;400(2):121-136. doi: 10.1007/s00441-024-03924-4. Epub 2024 Oct 11.
The Kupffer cell was first discovered by Karl Wilhelm von Kupffer in 1876, labeling them as "Sternzellen." Since their discovery as the primary macrophages of the liver, researchers have gradually gained an in-depth understanding of the identity, functions, and influential role of Kupffer cells, particularly in infection. It is becoming clear that Kupffer cells perform important tissue-specific functions in homeostasis and disease. Stationary in the sinusoids of the liver, Kupffer cells have a high phagocytic capacity and are adept in clearing the bloodstream of foreign material, toxins, and pathogens. Thus, they are indispensable to host defense and prevent the dissemination of bacteria during infections. To highlight the importance of this cell, this review will explore the history of the Kupffer cell in the context of infection beginning with its discovery to the present day.
枯否细胞于1876年由卡尔·威廉·冯·库普弗首次发现，并将它们标记为“星状细胞”。自从它们被发现是肝脏的主要巨噬细胞以来，研究人员逐渐对枯否细胞的特性、功能及其影响作用，尤其是在感染方面，有了更深入的了解。越来越明显的是，枯否细胞在体内平衡和疾病中发挥着重要的组织特异性功能。枯否细胞固定在肝脏血窦中，具有很高的吞噬能力，善于清除血液中的异物、毒素和病原体。因此，它们对宿主防御至关重要，并在感染期间防止细菌传播。为了突出这种细胞的重要性，本综述将从枯否细胞的发现到当今，在感染的背景下探讨其历史。
