Key Laboratory of Quantum Materials and Devices of Ministry of Education, School of Physics, Southeast University, Nanjing, 211189 China.
State Key Laboratory on Tunable Laser Technology, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055 China.
Nano Lett. 2024 Oct 23;24(42):13447-13454. doi: 10.1021/acs.nanolett.4c04267. Epub 2024 Oct 11.
Uric acid is typically measured through blood tests, which can be inconvenient and uncomfortable for patients. Herein, we propose a wearable surface-enhanced Raman scattering (SERS) chip, incorporating a hydrogel membrane with integrated plasmonic trimers, for noninvasive monitoring of uric acid in sweat. The plasmonic trimers feature sub 5 nm nanogaps, generating strong electromagnetic fields to boost the Raman signal of surrounding molecules. Simultaneously, the hydrogel membrane pumps sweat through these gaps, efficiently capturing sweat biomarkers for SERS detection. The chip can achieve saturation adsorption of sweat within 5 min, eliminating variations in individual sweat production rates. Dynamic SERS tracking of uric acid and lactic acid levels during anaerobic exercise reveals a temporary suppression of uric acid metabolism, likely due to metabolic competition with lactic acid. Furthermore, long-term monitoring correlates well with blood test results, confirming that regular exercise helps reduce serum uric acid levels and supporting its potential in managing hyperuricemia.
尿酸通常通过血液测试来测量，但这对患者来说既不方便也不舒服。在此，我们提出了一种可穿戴的表面增强拉曼散射（SERS）芯片，该芯片包含带有集成等离子体三聚体的水凝胶膜，可用于无创监测汗液中的尿酸。等离子体三聚体具有小于 5nm 的纳米间隙，可产生强电磁场，从而增强周围分子的拉曼信号。同时，水凝胶膜通过这些间隙泵送汗液，有效地捕获用于 SERS 检测的汗液生物标志物。该芯片可在 5 分钟内实现汗液的饱和吸附，消除个体汗液产生率的差异。在无氧运动过程中对尿酸和乳酸水平的动态 SERS 跟踪显示，尿酸代谢暂时受到抑制，这可能是由于与乳酸的代谢竞争。此外，长期监测与血液测试结果相关性良好，证实定期运动有助于降低血清尿酸水平，并支持其在管理高尿酸血症方面的潜力。
