State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Analyst. 2023 Jun 26;148(13):2965-2974. doi: 10.1039/d3an00591g.
A wearable sweat sensor, which could continuously monitor biomolecules related to the human physiological state, is emerging as a promising piece of health surveillance equipment. However, current sensors cannot simultaneously achieve a detection performance that equates to that of traditional sensors and satisfactory mechanical strength. Herein, a wearable sweat sensor with excellent detection performance and mechanical stability is designed and fabricated. Based on the integration of laser-induced graphene electrodes and a screen printing technique, this wearable sweat sensor could realize both the separate and simultaneous detection of uric acid (UA), tyrosine (Tyr), and ascorbic acid (AA) with high sensitivity. Good UA sensing performance in artificial sweat could be maintained even after 20 000 bends. In addition, the sensor can operate well in the wearing state or in a complex bovine whole blood sample. For the detection of human sweat, the changes in UA concentration after a purine-rich meal are continuously monitored and the results are in accordance with the corresponding serum UA detection results tested with a commercial serum UA meter. These results suggest its application potential in health monitoring for both gout patients and healthy humans.
一种可穿戴汗液传感器，可以连续监测与人体生理状态相关的生物分子，正在成为一种很有前途的健康监测设备。然而，目前的传感器不能同时实现等同于传统传感器的检测性能和令人满意的机械强度。本文设计并制作了一种具有优异检测性能和机械稳定性的可穿戴汗液传感器。基于激光诱导石墨烯电极和丝网印刷技术的集成，这种可穿戴汗液传感器可以实现尿酸（UA）、酪氨酸（Tyr）和抗坏血酸（AA）的单独和同时检测，具有高灵敏度。即使经过 20000 次弯曲，在人工汗液中的良好 UA 传感性能也能得以保持。此外，该传感器在佩戴状态或复杂的牛全血样本中也能正常工作。在对人体汗液的检测中，连续监测富含嘌呤的膳食后 UA 浓度的变化，结果与用商用血清 UA 计检测的相应血清 UA 检测结果一致。这些结果表明，它在痛风患者和健康人群的健康监测中有应用潜力。
