Tabatabai Tayebeh Sadat, Salehi Majid, Rezakhani Leila, Arabpour Zohreh, Djalilian Ali R, Alizadeh Morteza
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran; Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Tissue Cell. 2024 Dec;91:102573. doi: 10.1016/j.tice.2024.102573. Epub 2024 Oct 5.
Due to the increase in demand for donor organs and tissues during the past 20 years, new approaches have been created. These methods include, for example, tissue engineering in vitro and the production of regenerative biomaterials for transplantation. Applying the natural extracellular matrix (ECM) as a bioactive biomaterial for clinical applications is a unique approach known as decellularization technology. Decellularization is the process of eliminating cells from an extracellular matrix while preserving its natural components including its structural and functional proteins and glycosaminoglycan. This can be achieved by physical, chemical, or biological processes. A naturally formed three-dimensional structure with a biocompatible and regenerative structure is the result of the decellularization process. Decreasing the biological factors and antigens at the transplant site reduces the risk of adverse effects including inflammatory responses and immunological rejection. Regenerative medicine and tissue engineering applications can benefit from the use of decellularization, a promising approach that provides a biomaterial that preserves its extracellular matrix.
由于在过去20年中对供体器官和组织的需求增加，已经创造了新的方法。这些方法包括，例如，体外组织工程和用于移植的再生生物材料的生产。将天然细胞外基质（ECM）用作临床应用的生物活性生物材料是一种独特的方法，称为脱细胞技术。脱细胞是从细胞外基质中去除细胞的过程，同时保留其天然成分，包括其结构和功能蛋白以及糖胺聚糖。这可以通过物理、化学或生物学过程来实现。脱细胞过程的结果是形成具有生物相容性和再生结构的天然三维结构。减少移植部位的生物因子和抗原可降低包括炎症反应和免疫排斥在内的不良反应风险。再生医学和组织工程应用可以受益于脱细胞技术的使用，这是一种有前途的方法，可提供保留其细胞外基质的生物材料。
