School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109942. doi: 10.1016/j.msec.2019.109942. Epub 2019 Jul 3.
Decellularized matrix (dECM) is isolated extracellular matrix of tissues from its original inhabiting cells, which has emerged as a promising natural biomaterial for tissue engineering, aiming at support, replacement or regeneration of damaged tissues. The dECM can be easily obtained from tissues/organs of various species by adequate decellularization methods, and mimics the structure and composition of the native extracellular matrix, providing a favorable cellular environment. In this review, we summarize the recent developments in the preparation of dECM materials, including decellularization, crosslinking and sterilization. Also, we cover the advances in the utilization of dECM biomaterials in regeneration medicine in pre-clinic and clinical trials. Moreover, we highlight those emerging medical benefits of dECM beyond tissue engineering, such as cell transplantation, in vitro/in vivo model and therapeutic cues delivery. With the advances in the preparation and broader application, the dECM biomaterials could become the gold scaffold and pharmaceutical excipients in medical sciences.
去细胞基质 (dECM) 是从其原始栖息细胞中分离出的组织细胞外基质，它已成为组织工程中一种有前途的天然生物材料，旨在支持、替代或再生受损组织。通过适当的去细胞化方法，dECM 可以很容易地从各种物种的组织/器官中获得，并模拟天然细胞外基质的结构和组成，为细胞提供有利的环境。在这篇综述中，我们总结了 dECM 材料制备的最新进展，包括去细胞化、交联和灭菌。此外，我们还介绍了 dECM 生物材料在临床前和临床试验中再生医学中的应用进展。此外，我们还强调了 dECM 在组织工程之外的新兴医疗益处，例如细胞移植、体外/体内模型和治疗信号传递。随着制备技术的进步和更广泛的应用，dECM 生物材料可能成为医学科学中的黄金支架和药物赋形剂。
