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干扰素诱导产生的与抗流感病毒小鼠的Mx蛋白具有同源性的人蛋白。

Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice.

作者信息

Staeheli P, Haller O

出版信息

Mol Cell Biol. 1985 Aug;5(8):2150-3. doi: 10.1128/mcb.5.8.2150-2153.1985.

DOI:10.1128/mcb.5.8.2150-2153.1985
PMID:3939324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366934/
Abstract

Polyclonal and monoclonal antibodies with specificity for protein Mx (a karyophilic 75,000-dalton protein induced by interferon [IFN] in mouse cells carrying the influenza virus resistance allele Mx+) detected an IFN-induced 80,000-dalton protein in peripheral blood lymphocytes and in fibroblasts of healthy human donors. The human protein, like protein Mx, was induced by IFN-alpha but not by IFN-gamma. Unlike the mouse protein, it was predominantly localized in the cell cytoplasm.

摘要

对Mx蛋白（一种由干扰素[IFN]在携带流感病毒抗性等位基因Mx +的小鼠细胞中诱导产生的亲核性75,000道尔顿蛋白）具有特异性的多克隆抗体和单克隆抗体，在健康人类供体的外周血淋巴细胞和成纤维细胞中检测到一种IFN诱导的80,000道尔顿蛋白。这种人类蛋白与Mx蛋白一样，由IFN-α诱导产生，但不由IFN-γ诱导产生。与小鼠蛋白不同，它主要定位于细胞质中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/aef8944b06b7/molcellb00104-0352-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/abf7685a6653/molcellb00104-0350-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/44a5491ddfa8/molcellb00104-0351-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/5b81e1099f45/molcellb00104-0352-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/aef8944b06b7/molcellb00104-0352-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/abf7685a6653/molcellb00104-0350-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/44a5491ddfa8/molcellb00104-0351-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/5b81e1099f45/molcellb00104-0352-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618c/366934/aef8944b06b7/molcellb00104-0352-b.jpg

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本文引用的文献

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Virology. 1984 Jan 30;132(2):456-61. doi: 10.1016/0042-6822(84)90050-3.
2
A comparison of vertebrate interferon gene families detected by hybridization with human interferon DNA.通过与人类干扰素DNA杂交检测到的脊椎动物干扰素基因家族的比较。
J Mol Biol. 1983 Jun 5;166(4):457-75. doi: 10.1016/s0022-2836(83)80281-2.
3
Interferon induction of fibroblast proteins with guanylate binding activity.
从 APOBEC 到 ZAP：细胞限制因子抑制病毒感染的多种机制。
Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):382-394. doi: 10.1016/j.bbamcr.2018.09.012. Epub 2018 Oct 2.
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In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.禽流感病毒在体内对Mx蛋白的逃避需要病毒核蛋白具有人类特征。
J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.
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The oncolytic peptide LTX-315 triggers immunogenic cell death.溶瘤肽LTX-315可引发免疫原性细胞死亡。
Cell Death Dis. 2016 Mar 10;7(3):e2134. doi: 10.1038/cddis.2016.47.
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Mx proteins: antiviral gatekeepers that restrain the uninvited.Mx 蛋白：抑制不速之客的抗病毒守门员。
Microbiol Mol Biol Rev. 2013 Dec;77(4):551-66. doi: 10.1128/MMBR.00024-13.
7
The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity.鸡 MX 的细胞质定位不是其缺乏抗病毒活性的决定因素。
PLoS One. 2010 Aug 16;5(8):e12151. doi: 10.1371/journal.pone.0012151.
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9
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