Rice Samuel L, Berry-Tony Sagine, Benjamin Jamaal, Kapur Payal, Alnablsi Wisam, Lamus Daniel, Beets-Tan Regina, Pillai Anil
Department of Radiology, Netherlands Cancer Institute-Antoni van Leeuwenhoekziekenhuis, Amsterdam, the Netherlands; Interventional Radiology Section, Department of Radiology, UT Southwestern Medical Center, Dallas, Texas.
Interventional Radiology Section, Department of Radiology, Washington University Mallinckrodt Institute of Radiology at Barnes-Jewish Hospital, St. Louis, Missouri.
J Vasc Interv Radiol. 2025 Jan;36(1):168-174. doi: 10.1016/j.jvir.2024.09.027. Epub 2024 Oct 10.
To determine the effect of arterial embolization using different embolic agents and sizes on microwave ablation (MWA) zone size in a porcine renal tumor (RT) model.
In a transgenic porcine kidney, 32 sites were inoculated, with 28 orthotopic RTs induced. Experimental groups (23 tumors) underwent angiography with arterial embolization using various embolic materials (calibrated particles from 40 to 1,200 μm, and ethiodized oil) to achieve vascular stasis of the RT. MWA using a standard protocol (3 minutes at 65 W) was subsequently performed for all tumors. Gross and histologic ex vivo analyses of the ablation zones were performed.
Control group ablation zone volume without prior embolization was 5.24 cm (SD ± 0.55). Ablation zones after embolization with 40 μm, 100 μm, 300-500 μm, 900-1,200 μm particles were significantly larger than those with MWA alone (mean, 15.39 cm [SD ± 4.54]; P = .002; 11.07 cm [SD ± 1.39]; P = .001; 8.68 cm [SD ± 0.77]; P = .001; and 9.90 cm [SD ± 1.62]; P = .002, respectively). Liquid embolic ethiodized oil emulsion did not create a significant increase in the ablation zone (5.92 cm [SD ± 1.43 cm]; P = .492).
Pre-MWA arterial embolization in a porcine RT model produced a statistically significant increase in the ablation zone when compared with MWA alone. Using smaller particle size embolic material with distal embolization at the tumor arterioles (50-150 μm) produced the largest, almost 3-fold increase in ablation zone volume.
在猪肾肿瘤（RT）模型中，确定使用不同栓塞剂和大小进行动脉栓塞对微波消融（MWA）区域大小的影响。
在一只转基因猪的肾脏中接种32个位点，诱导产生28个原位RT。实验组（23个肿瘤）使用各种栓塞材料（校准颗粒直径从40至1200μm，以及碘化油）进行动脉栓塞血管造影，以实现RT的血管淤滞。随后对所有肿瘤进行标准方案（65W，3分钟）的MWA。对消融区域进行大体和组织学离体分析。
未预先栓塞的对照组消融区域体积为5.24cm（标准差±0.55）。用40μm、100μm、300 - 500μm、900 - 1200μm颗粒栓塞后的消融区域明显大于单纯MWA组（平均值分别为15.39cm（标准差±4.54）；P = 0.002；11.07cm（标准差±1.39）；P = 0.001；8.68cm（标准差±0.77）；P = 0.001；以及9.90cm（标准差±1.62）；P = 0.002）。液体栓塞剂碘化油乳剂未使消融区域显著增大（5.92cm（标准差±1.43cm）；P = 0.492）。
在猪RT模型中，与单纯MWA相比，MWA前进行动脉栓塞使消融区域有统计学意义的增大。使用较小粒径的栓塞材料在肿瘤小动脉处进行远端栓塞（50 - 150μm）可使消融区域体积增大最为明显，几乎增大3倍。
