Guan Rui, Wei Na, Cao Meng, Yang Jian-Gong, Wu Ru, Li Hui
Department of Inspection, Hanzhong People's Hospital, Hanzhong, PR China.
Department of Transfusion, Hanzhong People's Hospital, Hanzhong, PR China.
Parasitol Int. 2025 Feb;104:102980. doi: 10.1016/j.parint.2024.102980. Epub 2024 Oct 10.
The investigation of important prevalent tick-borne pathogens is central to the control of tick-borne diseases. To understand the prevalence of Borrelia burgdorferi s.l., Borrelia miyamotoi, and the Alongshan virus in ticks and patients in Shaanxi Province, China, a total of 670 adult ticks and 524 patient blood samples were collected in the region between 2022 and 2023. In this study, PCR was used to estimate the prevalence of the three pathogens. The results revealed that the overall positive rates of B. burgdorferi s.l, B. miyamotoi, and ALSV infection in the collected ticks were 13.58 %, 2.46 %, and 4.17 %, respectively. Three genospecies of B. burgdorferi s.l. were detected in this study, namely, B. garinii, B. afzelii, and B. bavariensis, with positive rates of 4.63 %, 3.58 %, and 5.37 %, respectively. The prevalence rates of B. miyamotoi, ALSV and B. burgdorferi s.l. in the patients were 0.38 %, 0.95 %, and 15 %, respectively. Moreover, B. burgdorferi s.l. and ALSV coinfection was also detected in three patients. Evolutionary analysis revealed that the isolate of B. miyamotoi belongs to the Asian type (Siberian type) and that of ALSV is closely related to that of Finland. To our knowledge, this is the first report on B. miyamotoi and ALSV detection in both ticks and humans in Shaanxi Province; the prevalence indicates that the regions in this province might be endemic areas. The results also suggest that humans in these regions are at risk of infection with these three tick-borne diseases.
对重要的蜱传病原体进行调查是控制蜱传疾病的核心。为了解中国陕西省蜱虫和患者中伯氏疏螺旋体狭义种、宫本疏螺旋体及阿龙山病毒的流行情况，于2022年至2023年期间在该地区共采集了670只成年蜱虫和524份患者血液样本。在本研究中，采用聚合酶链反应（PCR）来评估这三种病原体的流行率。结果显示，采集的蜱虫中伯氏疏螺旋体狭义种、宫本疏螺旋体及阿龙山病毒感染的总体阳性率分别为13.58%、2.46%和4.17%。本研究检测到伯氏疏螺旋体狭义种的三个基因种，即伽氏疏螺旋体、阿氏疏螺旋体和巴伐利亚疏螺旋体，阳性率分别为4.63%、3.58%和5.37%。患者中宫本疏螺旋体、阿龙山病毒及伯氏疏螺旋体狭义种的流行率分别为0.38%、0.95%和15%。此外，还在三名患者中检测到伯氏疏螺旋体狭义种与阿龙山病毒的合并感染。进化分析表明，宫本疏螺旋体的分离株属于亚洲型（西伯利亚型），阿龙山病毒的分离株与芬兰的分离株密切相关。据我们所知，这是陕西省蜱虫和人类中宫本疏螺旋体及阿龙山病毒检测的首次报告；该流行率表明该省这些地区可能为流行区。结果还表明，这些地区的人类有感染这三种蜱传疾病的风险。
