低强度经颅超声刺激调节阿尔茨海默病小鼠模型的神经血管耦合。

Low-intensity transcranial ultrasound stimulation modulates neurovascular coupling in mouse models of Alzheimer's disease.

机构信息

School of Electrical Engineering, Yanshan University, No. 438, Hebei Street, Qinhuangdao 066004, China.

Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, No. 438, Hebei Street, Qinhuangdao 066004, China.

出版信息

Cereb Cortex. 2024 Oct 3;34(10). doi: 10.1093/cercor/bhae413.

DOI:10.1093/cercor/bhae413

PMID:39393920

Abstract

Neurovascular coupling plays an important role in the progression of Alzheimer's disease. However, it is unclear how ultrasound stimulation modulates neurovascular coupling in Alzheimer's disease. Here, we found that (i) transcranial ultrasound stimulation modulates the time domain and frequency domain characteristics of cerebral blood oxygen metabolism in Alzheimer's disease mice; (ii) transcranial ultrasound stimulation can significantly modulate the relative power of theta and gamma frequency of local field potential in Alzheimer's disease mice; and (iii) transcranial ultrasound stimulation can significantly modulate the neurovascular coupling in time domain and frequency domain induced by forepaw electrical stimulation in Alzheimer's disease mice. It provides a research basis for the clinical application of transcranial ultrasound stimulation in Alzheimer's disease patients.

摘要

神经血管耦联在阿尔茨海默病的进展中起着重要作用。然而，目前尚不清楚超声刺激如何调节阿尔茨海默病中的神经血管耦联。在这里，我们发现：（i）经颅超声刺激调节阿尔茨海默病小鼠脑血氧代谢的时域和频域特征；（ii）经颅超声刺激可显著调节阿尔茨海默病小鼠局部场电位的θ和γ频带的相对功率；（iii）经颅超声刺激可显著调节阿尔茨海默病小鼠前爪电刺激诱导的时频域神经血管耦联。为经颅超声刺激在阿尔茨海默病患者中的临床应用提供了研究基础。