Thanneru Sindhura, Sikka Kapil, Bhalla Ashu Seith, Tripathi Madhavi, Thakar Alok, Singh Anup, Singh Chirom Amit, Verma Hitesh
All India Institute of Medical Sciences , New Delhi, India.
All India Institute of Medical Sciences, New Delhi, India.
Eur Arch Otorhinolaryngol. 2025 Mar;282(3):1171-1177. doi: 10.1007/s00405-024-09006-z. Epub 2024 Oct 11.
Primary: To explore criteria for treatment endpoint in NOE. Secondary: To study correlation of inflammatory markers, Erythrocyte sedimentation Rate (ESR) and C-reactive protein (CRP) with disease status.
Prospective cohort study conducted in a tertiary care hospital over two years (2021-2023) consisted 28 patients with NOE. Treatment culmination point was decided based on symptoms control and correlated with PET-scan findings. Clinical response was analysed with respect to the serum inflammatory markers and PET Scan findings.
There was fair degree of agreement between clinical resolution and resolution of findings on PET scan (kappa coefficient - 0.76 [95% CI; 0.40,1.00]). Inflammatory markers showed statistically significant decline with clinical resolution but failed to return to normal.
Decision to terminate treatment of NOE can be reliably made on clinical grounds in patients remaining asymptomatic for three weeks. Resolution of inflammation on PET scan is in congruity with the clinical remission .
主要目的：探索坏死性外耳道炎（NOE）治疗终点的标准。次要目的：研究炎症标志物、红细胞沉降率（ESR）和C反应蛋白（CRP）与疾病状态的相关性。
在一家三级护理医院进行了为期两年（2021 - 2023年）的前瞻性队列研究，纳入了28例坏死性外耳道炎患者。治疗终点根据症状控制情况确定，并与PET扫描结果相关联。分析了血清炎症标志物和PET扫描结果的临床反应。
临床缓解与PET扫描结果的缓解之间存在相当程度的一致性（kappa系数 - 0.76 [95% CI；0.40, 1.00]）。炎症标志物随着临床缓解呈现出统计学上的显著下降，但未能恢复正常。
对于无症状持续三周的患者，可基于临床依据可靠地做出终止坏死性外耳道炎治疗的决定。PET扫描上炎症的消退与临床缓解一致。
