Kario Kazuomi, Tomitani Naoko, Haimoto Koki, Narita Keisuke, Komi Ryosuke, Koba Shinji, Shimizu Hidekazu, Ohbayashi Hiroyuki, Fujiwara Takeshi, Kabutoya Tomoyuki, Kihara Hajime, Sekizuka Hiromitsu, Mizuno Hiroyuki, Abe Yasuhisa, Haimoto Hajime, Harada Kenji, Hoshide Satoshi
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
Washiya Memorial Hospital, Tochigi, Japan.
Hypertens Res. 2025 Feb;48(2):592-603. doi: 10.1038/s41440-024-01930-1. Epub 2024 Oct 12.
There is growing evidence that nocturnal hypertension is an independent risk factor for cardiovascular diseases, including heart failure. However, brachial blood pressure (BP) measurements during sleep might themselves disturb sleep quality. We initiated a nationwide, multicenter observational prospective study using a wrist-type oscillometric nighttime BP monitoring device with new algorithms to measure supine BP accurately without sleep disturbance. This study, named the Wrist ICT-based Sleep and Circadian Blood Pressure Monitoring Program-Night BP Study (WISDOM-Night Study), was designed to clarify the impact of wrist-measured daily nighttime BPs on cardiovascular prognosis (stroke, coronary artery disease, heart failure, etc.) using 7 days of BP measurements at 2:00 a.m., 3:00 a.m., 4:00 a.m., and 4 h after bedtime. A total of 2751 patients with one or more cardiovascular risk factors were recruited between March 2021 and March 2024 and are currently being followed up for 7 years. Additionally, 1416 of the WISDOM-Night Study-enrolled patients who also agreed to participate in the WISDOM-Hypertension-Mediated Organ Damage (HMOD) Study underwent echocardiography to evaluate the association between wrist-measured BP and left ventricular structure. Data from this WISDOM-Night Study should provide the prospective association between nighttime BP and cardiovascular disease and reveal the indexes of nighttime BP with clinical pathological relevance. This first report of the WISDOM-Night Study describes the study design, baseline characteristics, and BP control status.
越来越多的证据表明，夜间高血压是包括心力衰竭在内的心血管疾病的独立危险因素。然而，睡眠期间测量肱动脉血压本身可能会干扰睡眠质量。我们启动了一项全国性、多中心观察性前瞻性研究，使用一种腕式示波夜间血压监测设备及新算法，在不干扰睡眠的情况下准确测量仰卧位血压。这项名为基于腕部ICT的睡眠与昼夜血压监测项目-夜间血压研究（WISDOM-夜间研究）的研究，旨在通过在凌晨2点、3点、4点以及就寝后4小时测量7天的血压，阐明腕部测量的每日夜间血压对心血管预后（中风、冠状动脉疾病、心力衰竭等）的影响。2021年3月至2024年3月期间，共招募了2751名有一个或多个心血管危险因素的患者，目前正在对其进行为期7年的随访。此外，1416名同意参与WISDOM-高血压介导器官损害（HMOD）研究的WISDOM-夜间研究入组患者接受了超声心动图检查，以评估腕部测量的血压与左心室结构之间的关联。WISDOM-夜间研究的数据应能提供夜间血压与心血管疾病之间的前瞻性关联，并揭示具有临床病理相关性的夜间血压指标。WISDOM-夜间研究的这份首份报告描述了研究设计、基线特征和血压控制状况。
