Rao Jiayue, Tao Zhaoyang, Chen Jianshu, Yang Shengli
The College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Nat Prod Res. 2024 Oct 12:1-5. doi: 10.1080/14786419.2024.2412836.
The endophytic fungus , capable of producing bioactive substances, was isolated from the roots of Thunb. Through chromatographic methods, five compounds were isolated in this study for the first time from the fermentation broth and mycelia of the endophytic fungus obtained from Thunb. using ethyl acetate extracts. These compounds were identified as palmitic acid (), protocatechuic acid (), 4-hydroxybenzophenone (), stigmasterol (), and β-sitosterol (). The IC values for compound was 1.32 mg/mL, which indicate strong DPPH radical scavenging activity. Compounds , , and significantly inhibited the growth of , demonstrating MIC values of 6.25, 3.13, and 3.13 mg/mL, respectively. Additionally, displaying a MIC value of 0.78 mg/mL, compound demonstrated remarkable inhibition against growth. These findings suggest the presence of endophytic fungi in , producing several valuable medicinal secondary metabolites.
从海州常山的根部分离出了一种能够产生生物活性物质的内生真菌。通过色谱方法，本研究首次从海州常山内生真菌的发酵液和菌丝体中，使用乙酸乙酯提取物分离出了五种化合物。这些化合物被鉴定为棕榈酸、原儿茶酸、4-羟基二苯甲酮、豆甾醇和β-谷甾醇。化合物的IC值为1.32mg/mL，表明其具有较强的清除DPPH自由基的活性。化合物、和显著抑制了的生长，其MIC值分别为6.25、3.13和3.13mg/mL。此外，化合物对生长的抑制作用显著，MIC值为0.78mg/mL。这些发现表明海州常山存在内生真菌，能产生几种有价值的药用次生代谢产物。
