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肌内黏液瘤:关于肿瘤自发缩小的罕见观察

Intramuscular myxoma: unusual observation of spontaneous tumor size shrinkage.

作者信息

Khoury Charbel El, Taihi Lokmane, Evrard Robin, De Roo An-Katrien, Lecouvet Frédéric, Schubert Thomas

机构信息

Department of Orthopedic and Trauma Surgery, Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), Hippocrate Avenue 10, B-1200, Brussels, Belgium.

Department of Radiology and Medical Imaging, Cliniques Universitaires Saint Luc, Université Catholique de Louvain (UCLouvain), Hippocrate Avenue 10/2942, B-1200, Brussels, Belgium.

出版信息

Skeletal Radiol. 2025 Jun;54(6):1347-1352. doi: 10.1007/s00256-024-04813-1. Epub 2024 Oct 12.

DOI:10.1007/s00256-024-04813-1
PMID:39395033
Abstract

Soft tissue tumors, whether benign or malignant, may grow over time or remain stable, but they usually do not spontaneously decrease in size. However, there are exceptions, such as inflammatory conditions, desmoid tumors, or benign cysts. Intramuscular myxomas are benign soft tissue tumors that typically present as a solitary, slow-growing, painless mass. They are generally treated by surgical resection, after which recurrence is rare. Here, we present a brief series of three unusual cases of intramuscular myxomas that spontaneously decreased in size. They were located in the cervical region, the right lower extremity, and the paravertebral lumbar region. Imaging findings and percutaneous biopsies confirmed the diagnosis in all cases. Follow-up imaging showed a spontaneous reduction in lesion volume over time, far exceeding the amount of tissue sample removed during biopsy. This unusual observation of spontaneous shrinkage may call into question the subsequent therapeutic approach to these lesions.

摘要

软组织肿瘤,无论良性还是恶性,可能会随时间增长或保持稳定,但通常不会自行缩小。然而,也有例外情况,如炎症性疾病、硬纤维瘤或良性囊肿。肌内黏液瘤是一种良性软组织肿瘤,通常表现为单个、生长缓慢、无痛性肿块。一般通过手术切除进行治疗,术后复发罕见。在此,我们简要介绍三例不寻常的肌内黏液瘤病例,这些病例的肿瘤大小自行缩小。它们分别位于颈部、右下肢和腰椎旁区域。影像学检查结果和经皮活检在所有病例中均确诊。随访影像学显示,随着时间推移,病变体积自发缩小,远远超过活检时切除的组织样本量。这种不寻常的自发缩小现象可能会对这些病变后续的治疗方法提出质疑。

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Intramuscular myxoma: unusual observation of spontaneous tumor size shrinkage.肌内黏液瘤:关于肿瘤自发缩小的罕见观察
Skeletal Radiol. 2025 Jun;54(6):1347-1352. doi: 10.1007/s00256-024-04813-1. Epub 2024 Oct 12.
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本文引用的文献

1
Intramuscular Myxoma of the Flexor Carpi Ulnaris Causing Cubital Tunnel Syndrome: A Case Report.尺侧腕屈肌肌内黏液瘤导致肘管综合征:一例报告
J Orthop Case Rep. 2024 Jul;14(7):135-139. doi: 10.13107/jocr.2024.v14.i07.4604.
2
Mazabraud's syndrome in female patients: Two case reports.女性患者的马扎布劳德综合征:两例病例报告。
World J Orthop. 2024 Jun 18;15(6):593-601. doi: 10.5312/wjo.v15.i6.593.
3
Surgical Treatment of Intramuscular Myxoma.肌内黏液瘤的外科治疗
Indian J Orthop. 2021 Feb 22;55(4):892-897. doi: 10.1007/s43465-021-00367-9. eCollection 2021 Aug.
4
Next generation sequencing for GNAS uncovers CD34 as a sensitive marker for intramuscular myxoma.下一代测序技术用于 GNAS 发现 CD34 是肌内黏液瘤的敏感标志物。
Ann Diagn Pathol. 2019 Dec;43:151409. doi: 10.1016/j.anndiagpath.2019.151409. Epub 2019 Oct 5.
5
Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review.马扎布劳德综合征:一例报告及最新文献综述。
Endocr Metab Immune Disord Drug Targets. 2019;19(6):885-893. doi: 10.2174/1871530319666181226103700.
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Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.检测肌内/细胞性黏液瘤中的GNAS突变作为黏液样软组织肿瘤分类的诊断工具。
Diagn Pathol. 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8.
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Post-biopsy MRI changes in the size and enhancement of intramuscular myxomas: A report of two cases.活检后肌内黏液瘤大小及强化的MRI变化:2例报告
Clin Imaging. 2018 Mar-Apr;48:55-61. doi: 10.1016/j.clinimag.2017.09.007. Epub 2017 Sep 28.
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Myxoid soft-tissue neoplasms: comprehensive update of the taxonomy and MRI features.黏液样软组织肿瘤:分类学与MRI特征的全面更新
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Mazabraud's syndrome. A case with multiple myxomas.马扎布雷德综合征。一例多发性黏液瘤。
Orthop Traumatol Surg Res. 2012 Jun;98(4):455-60. doi: 10.1016/j.otsr.2012.04.002. Epub 2012 May 18.
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Myxoma, the tumor of primitive mesenchyme.黏液瘤,一种原始间充质肿瘤。
Ann Surg. 1948 May;127(4):706-19.