Laboratory of Virology, Clinical Pathology Department, Centro Hospitalar e Universitário de Coimbra, Unidade Local de Saúde de Coimbra, Avenida Afonso Romão, Coimbra, 3000-602, Portugal.
Infectious Diseases Department, Centro Hospitalar e Universitário de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Eur J Clin Microbiol Infect Dis. 2024 Dec;43(12):2473-2476. doi: 10.1007/s10096-024-04959-9. Epub 2024 Oct 12.
To date, no studies comparing the prevalence of hepatitis E virus (HEV) infection between the general and human immunodeficiency virus 2 (HIV-2) populations are available. With the purpose of filling this gap, this prevalence was assessed in the HIV-2 population from central Portugal. HEV seropositivity was 19.4%, which did not differ significantly from that found in the matched control population, and was not associated with CD4 cell count, HIV-2 viral load, and geographic origin or travel history to regions considered highly endemic for HEV. The results suggest that HIV-2 is not a risk factor for HEV infection, neither for an increased occurrence of chronic HEV infection.
迄今为止，尚无研究比较普通人群和人类免疫缺陷病毒 2 型（HIV-2）人群中戊型肝炎病毒（HEV）感染的流行率。为了填补这一空白，本研究评估了来自葡萄牙中部的 HIV-2 人群中的 HEV 血清阳性率。HEV 血清阳性率为 19.4%，与匹配的对照组人群无显著差异，且与 CD4 细胞计数、HIV-2 病毒载量以及地理来源或前往被认为是 HEV 高度流行地区的旅行史无关。结果表明，HIV-2 不是 HEV 感染的危险因素，也不是慢性 HEV 感染发生率增加的危险因素。
