Iwamoto T, Wada H
Behav Neural Biol. 1985 May;43(3):311-6. doi: 10.1016/s0163-1047(85)91658-9.
Twenty one male albino rats of the Wistar strain were trained on a differential reinforcement of long latency 20 with a limited hold 36 schedule through 30 consecutive days. Six rats were injected into the medial septal area with 8 micrograms of 6-hydroxydopamine dissolved in 0.9% saline solution containing 0.1% ascorbic acid. Five rats were injected with only ascorbic acid solution and the remaining rats were not treated with any injection or surgical operation. As a result of this differential reinforcement of long latency training, the 6-hydroxydopamine-injected rats showed significantly better performance and less acceleration of lever pressing response just after nonreinforced responses (incorrect responses) compared with the other two control groups, especially in the early 10 sessions. These findings suggested that the 6-hydroxydopamine-injected rats were hardly affected by response acceleration following nonreinforcements and therefore could acquire this training schedule faster than could the controls. The authors proposed one probable hypothesis, that the catecholaminergic input to the septum mediated a frustrated emotional response such as response acceleration resulting from nonreinforcements and impaired behavioral inhibition in the time discrimination situation.
选用21只雄性Wistar品系白化大鼠，通过30天的连续训练，使其适应长潜伏期20次的差别强化程序，并设定有限的36次保持时间。向6只大鼠的内侧隔区注射溶解于含0.1%抗坏血酸的0.9%盐溶液中的8微克6-羟基多巴胺。5只大鼠仅注射抗坏血酸溶液，其余大鼠未接受任何注射或外科手术。经过这种长潜伏期训练的差别强化后，与其他两个对照组相比，注射6-羟基多巴胺的大鼠表现出明显更好的性能，并且在非强化反应（错误反应）后杠杆按压反应的加速程度更小，尤其是在前10次训练中。这些发现表明，注射6-羟基多巴胺的大鼠几乎不受非强化后反应加速的影响，因此比对照组能够更快地适应这种训练程序。作者提出了一个可能的假设，即向隔区的儿茶酚胺能输入介导了一种受挫的情绪反应，例如非强化导致的反应加速以及时间辨别情境中行为抑制的受损。
