Bark David L, Vital Eudorah F, Oury Cécile, Lam Wilbur A, Gardiner Elizabeth E
Department of Pediatrics, Division of Hematology and Oncology, Washington University in St. Louis, St. Louis, Missouri, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, Georgia, USA.
J Thromb Haemost. 2025 Jan;23(1):345-358. doi: 10.1016/j.jtha.2024.09.026. Epub 2024 Oct 10.
Blood flow is vital to life, yet disturbed flow has been linked to atherosclerosis, thrombosis, and endothelial dysfunction. The commonly used hemodynamic descriptor "disturbed flow" found in disease and medical devices is not clearly defined in many studies. However, the specific flow regime-laminar, transitional, or turbulent-can have very different effects on hemostasis, thrombosis, and vascular health. Therefore, it remains important to clinically identify turbulence in cardiovascular flow and to have available assays that can be used to study effects of turbulence. The objective of the current communication was to 1) provide clarity and guidance for how to clinically identify turbulence, 2) define standard measures of turbulence that can allow the recreation of flow conditions in a benchtop assay, and 3) review how cells and proteins in the blood can be impacted by turbulence based on current literature.
血流对生命至关重要，但紊乱血流与动脉粥样硬化、血栓形成和内皮功能障碍有关。在疾病和医疗设备中常见的血流动力学描述词“紊乱血流”在许多研究中并未得到明确界定。然而，特定的血流状态——层流、过渡流或湍流——对止血、血栓形成和血管健康可能产生非常不同的影响。因此，临床上识别心血管血流中的湍流并拥有可用于研究湍流影响的检测方法仍然很重要。本通讯的目的是：1）为临床上如何识别湍流提供清晰的指导；2）定义湍流的标准测量方法，以便在台式检测中重现血流条件；3）根据现有文献综述血液中的细胞和蛋白质如何受到湍流的影响。
