The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Department of Cardiology, The First Affiliated Hospital of Guangdong University of Pharmacy, Guangzhou, Guangdong, 510080, China.
BMC Cardiovasc Disord. 2024 Oct 12;24(1):552. doi: 10.1186/s12872-024-04178-2.
Tricuspid regurgitation (TR) is common in patients evaluated by echocardiography. However, the prevalence and contributing factors of the disease remain limited. This hospital-based study was designed to analyze adult patients first diagnosed with tricuspid regurgitation by Doppler echocardiography to determine the prevalence and characteristics of clinically meaningful TR.
A total of 22,317 patients over the age of 18 who underwent echocardiography at the Cardiac Ultrasound Center of the First Affiliated Hospital of Guangdong Pharmaceutical University from July 1, 2015 to December 31, 2019 were collected. We collected basic information about the patients, including age, gender, history of heart disease, etc. Patients with valvular heart disease were assessed by transthoracic echocardiography. According to the degree of regurgitation and regurgitation, TR was divided into 6 grades (0-5). Pericardial effusion was recorded and bilateral atrial and ventricular diameters were measured. Logistic regression analysis was used to assess risk factors for significant TR (≥ grade 2 reflux).
A total of 2299 significant TR cases were found in people over 18 years old, accounting for 10.3% of the total population. The occurrence of TR was found to be closely related to age. The prevalence rates of significant TR in different groups were: 3.3% in the younger than 45-year-old group, 4.1% in the 46-55-year-old group, 5.8% in the 56-65-year-old group, 10.1% in the 66-75-year-old group, and the prevalence of significant TR rose directly to 22.3% in patients over 75-year-old group. Further logistic regression analysis showed that male, age, pacemaker, congenital heart disease, pericardial effusion, pulmonary hypertension, mitral regurgitation, left ventricular diastolic dysfunction and aortic regurgitation were associated with the occurrence of significant TR. Both RVD and RA-1 were effective predictors of significant TR, with RVD ≥ 33.5 mm having a sensitivity of 0.638, specificity of 0.675, and ROC curve area of 0.722. The sensitivity of RA1 ≥ 45.5 mm was 0.652, the specificity was 0.699, and the area under the ROC curve was 0.736.
TR is common in people undergoing echocardiography. Gender, age, pacemaker implantation, congenital heart disease, pericardial effusion, pulmonary hypertension, mitral insufficiency, and aortic insufficiency are the influencing factors of TR.
三尖瓣反流（TR）在接受超声心动图检查的患者中很常见。然而，该疾病的患病率和致病因素仍有限。本医院为基础的研究旨在分析首次通过多普勒超声心动图诊断为三尖瓣反流的成年患者，以确定临床上有意义的 TR 的患病率和特征。
收集 2015 年 7 月 1 日至 2019 年 12 月 31 日在广东药科大学第一附属医院心脏超声中心接受超声心动图检查的年龄在 18 岁以上的 22317 例患者的基本信息，包括年龄、性别、心脏病史等。通过经胸超声心动图评估瓣膜性心脏病患者。根据反流程度和反流程度，TR 分为 6 个等级（0-5）。记录心包积液并测量双侧心房和心室直径。采用 logistic 回归分析评估显著 TR（≥ 2 级反流）的危险因素。
在 18 岁以上的人群中，共发现 2299 例明显 TR 病例，占总人群的 10.3%。TR 的发生与年龄密切相关。不同组别的显著 TR 发生率分别为：45 岁以下组 3.3%，46-55 岁组 4.1%，56-65 岁组 5.8%，66-75 岁组 10.1%，年龄超过 75 岁组直接上升至 22.3%。进一步的 logistic 回归分析表明，男性、年龄、起搏器、先天性心脏病、心包积液、肺动脉高压、二尖瓣反流、左心室舒张功能障碍和主动脉瓣反流与显著 TR 的发生相关。RVD 和 RA-1 均是显著 TR 的有效预测因子，RVD≥33.5mm 的敏感性为 0.638，特异性为 0.675，ROC 曲线下面积为 0.722。RA1≥45.5mm 的敏感性为 0.652，特异性为 0.699，ROC 曲线下面积为 0.736。
TR 在接受超声心动图检查的人群中很常见。性别、年龄、起搏器植入、先天性心脏病、心包积液、肺动脉高压、二尖瓣关闭不全和主动脉瓣关闭不全是 TR 的影响因素。
