γδ T 细胞功能障碍与儿童慢性活动性 Epstein-Barr 病毒感染。
Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection.
机构信息
Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, 100045, China.
出版信息
Ital J Pediatr. 2024 Oct 12;50(1):213. doi: 10.1186/s13052-024-01783-x.
Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.
慢性活动性 EBV 感染（CAEBV）是一种进行性且危及生命的疾病，其特征为 EBV 持续或反复激活。据报道，γδ T 细胞是一种细胞毒性淋巴细胞，在限制 EBV 方面发挥着关键作用。然而，儿科 CAEBV 患者的 γδ T 细胞功能状态尚未被描述。在本研究中，通过流式细胞术分析来探索 CAEBV 患者 γδ T 细胞的细胞因子产生能力。研究发现 CAEBV 患者 γδ T 细胞的频率降低，细胞毒性分子颗粒酶 B 的表达减少，提示在这种疾病中 γδ T 细胞的免疫调节功能发生障碍。
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