Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Sci Rep. 2024 Oct 12;14(1):23891. doi: 10.1038/s41598-024-75305-4.
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37-0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry.
性激素（如雌二醇、睾酮和性激素结合球蛋白（SHBG））在女性中肺癌和结直肠癌（乳腺癌之后最常见的两种癌症）病因中的作用尚不清楚。本孟德尔随机化（MR）研究评估了欧洲血统女性中这些潜在的因果关联。我们使用了来自全基因组关联研究的性激素汇总统计数据，以及特隆赫姆健康研究（HUNT）和癌症大型联盟的数据。HUNT 研究中有提示性证据表明，总睾酮水平增加 1 个标准差与肺癌非腺癌风险降低相关（风险比 0.60，95%置信区间 0.37-0.98）。然而，这一结果并未得到更大联盟数据的证实。总体而言，我们没有发现令人信服的证据支持性激素对欧洲裔女性肺癌和结直肠癌风险的因果作用。
