Porcelli F, Barbareschi M, Mosca L, Bagnagatti De Giorgi A, Bianchi C
Helv Paediatr Acta. 1985 Apr;40(1):75-82.
A 10-month-old girl with sexual precocity of recent onset was found to have elevated levels of estrogens, progesterone and androgen precursors, associated with a polycystic left ovary. After ovariectomy, estrogen and androgen levels were normal, and the clinical symptoms began to regress. A few months later, a huge mediastinal mass was unexpectedly discovered. Removal of the mass, identified later as a benign teratoma, was followed by the total normalization of the clinical and hormonal findings. The patient's pseudo-precocious puberty might have been due to an ovarian overproduction of estroprogestins and androgens, associated with a paraneoplastic production of progesterone, or in theory, it might have been due to a gonadotropin-like stimulation of the ovary by the teratoma.
一名近期出现性早熟的10个月大女孩被发现雌激素、孕酮和雄激素前体水平升高，伴有左侧多囊卵巢。卵巢切除术后，雌激素和雄激素水平恢复正常，临床症状开始消退。几个月后，意外发现一个巨大的纵隔肿块。切除该肿块（后来确定为良性畸胎瘤）后，临床和激素检查结果完全恢复正常。该患者的假性性早熟可能是由于卵巢过度产生雌激素孕激素和雄激素，并伴有副肿瘤性孕酮产生，或者理论上，可能是由于畸胎瘤对卵巢的促性腺激素样刺激所致。
