Maihoub Stefani, Krasznai Magdolna, Molnár András
1 Semmelweis Egyetem, Általános Orvostudományi Kar, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika Budapest, Szigony u. 36., 1083 Magyarország.
Orv Hetil. 2024 Oct 13;165(41):1621-1627. doi: 10.1556/650.2024.33125.
The overuse of antibiotics has led to the development of antimicrobial resistance. As a result, topical antiseptics may become more important in clinical practice. Unlike antibiotics, antiseptics are less likely to induce resistance due to their unspecific mode of action and high local concentrations. However, there are challenges associated with using antiseptics, such as tolerability, inactivation by organic matter, and potential side effects. This review focuses on the challenges of using antiseptics, with a detailed discussion on the antimicrobial properties and possible resistances of octenidine dihydrochloride, povidone-iodine, hydrogen peroxide, chlorhexidine, and isopropyl alcohol antiseptics. The review also explores and discusses their antimicrobial efficacy, resistance, wound-healing properties, skin tolerability, and side effects. Orv Hetil. 2024; 165(41): 1621–1627.
抗生素的过度使用导致了抗菌药物耐药性的产生。因此，局部抗菌剂在临床实践中可能会变得更加重要。与抗生素不同，抗菌剂由于其非特异性作用方式和高局部浓度，不太可能诱导耐药性。然而，使用抗菌剂也存在一些挑战，如耐受性、被有机物灭活以及潜在的副作用。本综述重点关注使用抗菌剂的挑战，并详细讨论了二盐酸奥替尼啶、聚维酮碘、过氧化氢、氯己定和异丙醇抗菌剂的抗菌特性及可能产生的耐药性。该综述还探讨并讨论了它们的抗菌效果、耐药性、伤口愈合特性、皮肤耐受性和副作用。《匈牙利医学周报》。2024年；165(41):1621–1627。
