Perceptual and Cognitive Effects of Focal Transcranial Direct Current Stimulation of Auditory Cortex in Tinnitus.

OBJECTIVES

Transcranial direct current stimulation (tDCS) has been studied as a potential treatment for many brain conditions. Although tDCS is well tolerated, continued study of perceptual and cognitive side effects is warranted, given the complexity of functional brain organization. This study tests the feasibility of brief tablet-based tasks to assess auditory and cognitive side effects in a recently reported pilot study of auditory-cortex tDCS in chronic tinnitus and attempts to confirm that this untested multisession tDCS protocol does not worsen hearing.

MATERIALS AND METHODS

Participants with chronic tinnitus completed two hearing tasks (pure-tone thresholds, Words In Noise [WIN]) and two cognitive tasks (Flanker, Dimension Change Card Sort) from the NIH Toolbox (2024 Toolbox Assessments, Inc, Lincolnwood, IL). Participants were randomized to active or sham 4×1 silver/silver-chloride tDCS of left auditory cortex (n = 10/group). Tasks were completed immediately before and after the first tDCS session, and after the fifth/final tDCS session. Statistics included linear mixed-effects models for change in task performance over time.

RESULTS

Before tDCS, performance on both auditory tasks was highly correlated with clinical audiometry, supporting the external validity of these measures (r > 0.89 for all). Although overall auditory task performance did not change after active or sham tDCS, detection of right-ear WIN stimuli modestly improved after five active tDCS sessions (t = -2.07, p = 0.05). On cognitive tasks, reaction times (RTs) were quicker after sham tDCS, reflecting expected practice effects (eg, t = 3.22, p = 0.002 after five sessions on the Flanker task). However, RTs did not improve over repeated sessions in the active group, suggesting that tDCS interfered with learning these practice effects.

CONCLUSIONS

Repeated sessions of auditory-cortex tDCS do not seem to adversely affect hearing or cognition but may modestly improve hearing in noise and interfere with some types of motor learning. Low-burden cognitive/perceptual test batteries could be a powerful way to identify adverse effects and new treatment targets in brain stimulation research.