Kapinos Kandice A, Louis Elan D
RAND Corporation, Arlington, Virginia, USA,
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Neuroepidemiology. 2024 Oct 11:1-7. doi: 10.1159/000541968.
The aim of the study was to determine the direct medical cost of illness from essential tremor (ET) from a patient perspective.
Secondary data from the Optum's de-identified Clinformatics® Data Mart Database from 2018-2019 were used to assess medical resource utilization and costs. Propensity score matching was used to match patients aged 40+ to statistically similar controls. Generalized linear models were used to estimate average, adjusted total costs of care per year, by healthcare setting, and provider specialty.
The final sample included 41,200 patients with at least one ET claim and 36,871 matched patients. Overall, ET patients aged 40+ had about USD 28,217 in direct medical costs per year, which was about USD 1,601 more than matched comparisons (p < 0.001). This was driven by greater number of outpatient visits overall and with specialists. Extrapolating the estimates from our study and pairing them with published age-specific disease prevalence statistics for ET, we calculated an annual cost for direct medical care of ET patients aged 40+ to be about USD 9.4 billion.
The estimated direct medical costs among adults aged 40+ with an ET diagnosis aggregated to the population level are nontrivial.
本研究旨在从患者角度确定特发性震颤（ET）疾病的直接医疗成本。
利用Optum公司2018 - 2019年去识别化的临床信息学数据集市数据库中的二手数据，评估医疗资源利用情况和成本。倾向得分匹配法用于将40岁及以上患者与统计学上相似的对照组进行匹配。广义线性模型用于按医疗环境和医疗服务提供者专业估算每年的平均调整后总护理成本。
最终样本包括41,200名至少有一项ET索赔的患者和36,871名匹配患者。总体而言，40岁及以上的ET患者每年的直接医疗成本约为28,217美元，比匹配对照组高出约1,601美元（p < 0.001）。这是由于总体门诊就诊次数较多，尤其是专科门诊就诊次数较多所致。根据我们研究的估算结果，并结合已发表的ET特定年龄疾病患病率统计数据，我们计算出40岁及以上ET患者的直接医疗护理年度成本约为94亿美元。
40岁及以上被诊断为ET的成年人中，估计的直接医疗成本汇总到人群层面是相当可观的。
