Louis Elan D
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8813, USA.
Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-8813, USA.
J Clin Med. 2025 Apr 11;14(8):2637. doi: 10.3390/jcm14082637.
The objective is to systematically review evidence from clinical and epidemiological studies for or against an association between essential tremor (ET) and Parkinson's disease (PD). A literature search in PubMed (February 2025) used several combinations of keywords. Thirty-three studies (1960-2023) were identified. The best available data are derived from a population-based study in Spain, followed by a cohort study in the US. Each of these prospective studies provided evidence that ET is a risk factor for PD, with elevated risks of ~4-5. In cross-sectional studies, in which the proportion of PD cases with ET has been reported, the weight of evidence demonstrates an association between ET and PD. In 16 (88.9%) of 18 family studies, the odds ratios or hazards ratios are elevated-i.e., there is considerable evidence that ET is over-represented in PD families and, conversely, PD is over-represented in ET families. A comprehensive review of published data strongly supports an association between ET and PD and, more specifically, provides evidence that ET is a risk factor for PD. Seven of nine review articles (and six of seven non-commissioned review articles) have concluded that there is an association between these two degenerative diseases. The "controversy" that surrounds the ET-PD association is more of a repeated myth than a well-informed reality. As a field, it would be more productive to finally move beyond uniformed debate and focus our efforts on attempts to elucidate the basis for the association to which the data are repeatedly pointing.
目的是系统回顾临床和流行病学研究中支持或反对特发性震颤（ET）与帕金森病（PD）之间关联的证据。在PubMed（截至2025年2月）中进行文献检索时使用了多种关键词组合。共识别出33项研究（1960 - 2023年）。现有最佳数据来自西班牙的一项基于人群的研究，其次是美国的一项队列研究。每项前瞻性研究均提供证据表明ET是PD的一个风险因素，风险升高约4 - 5倍。在报告了伴有ET的PD病例比例的横断面研究中，证据权重显示ET与PD之间存在关联。在18项家族研究中的16项（88.9%）中，优势比或风险比升高，即有大量证据表明ET在PD家族中过度存在，反之，PD在ET家族中也过度存在。对已发表数据的全面回顾有力支持ET与PD之间存在关联，更具体地说，提供了ET是PD风险因素的证据。九篇综述文章中的七篇（以及七篇非委托综述文章中的六篇）得出结论，这两种退行性疾病之间存在关联。围绕ET - PD关联的“争议”更多是一个反复出现的误解，而非基于充分信息的现实。作为一个领域，最终超越无根据的争论，将我们的努力集中在试图阐明数据反复指向的这种关联的基础上，可能会更有成效。
