Bruno J P, Stricker E M, Zigmond M J
Behav Neurosci. 1985 Aug;99(4):771-5. doi: 10.1037//0735-7044.99.4.771.
Extensive damage to central dopamine (DA)-containing neurons are known to produce akinesia and sensory neglect when the lesions are made in adult rats. Similar behavioral impairments occur when dopaminergic function is disrupted temporarily by DA receptor blocking agents, and brain-damaged rats are particularly sensitive to the effects of those drugs. The present experiments offer a striking contrast to these well-accepted findings that central DA-containing neurons are critical to the initiation of voluntary movement. After near-total destruction of the dopaminergic neurons in 3-day-old rats, there were no conspicuous behavioral dysfunctions at any time during the subsequent 5-8 months, even when the animals were given large doses of DA receptor blocking agents. These findings suggest that some other neuronal system had replaced the absent dopaminergic neurons in the central control of movement.
已知在成年大鼠中制造损伤时，对中枢含多巴胺（DA）神经元的广泛损害会导致运动不能和感觉忽视。当多巴胺能功能被DA受体阻断剂暂时破坏时，会出现类似的行为障碍，并且脑损伤的大鼠对这些药物的作用特别敏感。目前的实验与这些广为接受的发现形成了鲜明对比，即中枢含DA神经元对自主运动的启动至关重要。在3日龄大鼠的多巴胺能神经元几乎完全被破坏后，在随后的5至8个月内的任何时候都没有明显的行为功能障碍，即使给动物大剂量的DA受体阻断剂也是如此。这些发现表明，在运动的中枢控制中，一些其他神经元系统已经取代了缺失的多巴胺能神经元。
