Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, China.
Department of Neurology, Shandong Provincial HospitalAffiliated to, Shandong First Medical University , Jinan, China.
BMC Med. 2024 Oct 14;22(1):458. doi: 10.1186/s12916-024-03672-w.
Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressing infectious disease with a high fatality rate caused by a novel bunyavirus (SFTSV). The role of lipids in viral infections is well-documented; however, the specific alterations in lipid metabolism during SFTSV infection remain elusive. This study aims to elucidate the lipid metabolic dysregulations in the early stages of SFTS patients.
This study prospectively collected peripheral blood sera from 11 critical SFTS patients, 37 mild SFTS patients, and 23 healthy controls during the early stages of infection for lipidomics analysis. A systematic bioinformatics analysis was conducted from three aspects integrating lipid differential expressions, lipid differential correlations, and lipid-clinical indices correlations to reveal the serum lipid metabolic dysregulation in SFTSV-infected individuals.
Our findings reveal significant lipid metabolic dysregulation in SFTS patients. Specifically, compared to healthy controls, SFTS patients exhibited three distinct modes of lipid differential expression: increased levels of lipids including phosphatidylserine (PS), hexosylceramide (HexCer), and triglycerides (TG); decreased levels of lipids including lysophosphatidylcholine (LPC), acylcarnitine (AcCa), and cholesterol esters (ChE); and lipids showing "dual changes" including phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Finally, based on lipid metabolic pathways and literature analysis, we systematically elucidated the potential mechanisms underlying lipid metabolic dysregulation in the early stage of SFTSV infection.
Our study presents the first global serum lipidome profile and reveals the lipid metabolic dysregulation patterns in the early stage of SFTSV infection. These findings provide a new basis for the diagnosis, treatment, and further investigation of the disease.
严重发热伴血小板减少综合征（SFTS）是一种由新型布尼亚病毒（SFTSV）引起的快速进展性传染病，死亡率高。脂质在病毒感染中的作用已有充分的文献记载；然而，SFTSV 感染过程中脂质代谢的具体变化仍不清楚。本研究旨在阐明 SFTS 患者早期的脂质代谢失调。
本研究前瞻性收集了 11 例重症 SFTS 患者、37 例轻症 SFTS 患者和 23 例健康对照者在感染早期的外周血血清，进行脂质组学分析。从脂质差异表达、脂质差异相关性和脂质-临床指标相关性三个方面进行系统的生物信息学分析，揭示 SFTSV 感染个体的血清脂质代谢失调。
我们的研究结果表明 SFTS 患者存在明显的脂质代谢失调。具体来说，与健康对照组相比，SFTS 患者表现出三种不同的脂质差异表达模式：包括磷脂酰丝氨酸（PS）、神经酰胺己糖（HexCer）和甘油三酯（TG）在内的脂质水平升高；包括溶血磷脂酰胆碱（LPC）、酰基肉碱（AcCa）和胆固醇酯（ChE）在内的脂质水平降低；以及包括磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）在内的脂质呈“双重变化”。最后，基于脂质代谢途径和文献分析，我们系统地阐明了 SFTSV 感染早期脂质代谢失调的潜在机制。
本研究首次提供了 SFTSV 感染早期的全血清脂质组学图谱，并揭示了脂质代谢失调模式。这些发现为疾病的诊断、治疗和进一步研究提供了新的依据。
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