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一名因感染 SFTS 病毒的病犬而感染严重发热伴血小板减少综合征(SFTS)的患者。

A Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected from a Sick Dog with SFTS Virus Infection.

机构信息

Oshima Animal Hospital, Japan.

Clinic Okumura, Japan.

出版信息

Jpn J Infect Dis. 2022 Jul 22;75(4):423-426. doi: 10.7883/yoken.JJID.2021.796. Epub 2022 Feb 28.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) caused by Dabie bandavirus (formerly SFTS virus, SFTSV), which belongs to the Bandavirus genus (formerly Phlebovirus genus) of the Phenuiviridae family (formerly Bunyaviridae family), is a tick-borne novel bunyavirus infection with high rates of mortality. SFTSV infection was diagnosed virologically in a 4-year-old dog with symptoms of lethargy and anorexia in western Japan in June 2017. The dog's owner, a man in his 40s, had taken care of the sick dog and became sick 10 days after disease onset in the dog, showing symptoms, such as fever, arthralgia, headache, nausea, and vomiting. Total blood cell counts revealed leukocytopenia and thrombocytopenia. He was treated as an outpatient. He had no scars suggesting that he had not been bitten by ticks. He was diagnosed as having SFTS via the detection of IgM and neutralizing antibodies to SFTSV. The patient was directly infected with SFTSV from the SFTSV-infected dog. In conclusion, humans can be at a risk of SFTSV infection through direct contact with sick dogs infected with SFTSV.

摘要

严重发热伴血小板减少综合征(SFTS)由大别山病毒(以前称为 SFTS 病毒,SFTSV)引起,属于白蛉病毒科(以前称为布尼亚病毒科)的班纳病毒属(以前称为菲蚊病毒属),是一种蜱传播的新型布尼亚病毒感染,死亡率很高。2017 年 6 月,在日本西部,一只出现嗜睡和食欲不振症状的 4 岁犬被诊断出感染了 SFTSV。该犬的主人是一名 40 多岁的男子,他曾照顾过这只生病的狗,在狗发病 10 天后,他开始出现发热、关节痛、头痛、恶心和呕吐等症状。全血细胞计数显示白细胞减少和血小板减少。他被作为门诊病人进行治疗。他没有被蜱叮咬的痕迹。通过检测 SFTSV 的 IgM 和中和抗体,他被诊断为患有 SFTS。该患者是通过直接接触感染 SFTSV 的 SFTSV 感染犬而被 SFTSV 直接感染。总之,人类可能因直接接触感染 SFTSV 的患病犬而感染 SFTSV。

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