Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sci Rep. 2024 Oct 13;14(1):23924. doi: 10.1038/s41598-024-74151-8.
Iron deficiency anemia (IDA) is prevalent in exclusively breastfed (EBF) Thai infants. However, in Thailand, iron supplementation guidelines for EBF infants are not available. This prospective open-label study aimed to estimate the prevalence of IDA in 9-month-old EBF infants after receiving iron supplementation from 4 months of age until they consumed adequate iron-rich food. Forty-seven healthy, 4-month-old EBF infants were prescribed 1 mg/kg/day ferrous sulfate. Their complementary food records from 6 to 9 months were calculated for daily iron intake. Complete blood count and iron study were performed at 9 months of age. The results showed that the prevalence of IDA at 9 months was 6.4%. An employed caregiver and the male sex of the baby were significantly associated with iron deficiency. The food record revealed that the median daily iron intake was less than the Thai dietary reference intake recommendation. In summary, the prevalence of IDA in infants with 9 months of exclusive breastfeeding who received iron supplementation was lower than the background rate (25.7%) when iron was not prescribed. Most infants did not have adequate iron in complementary foods. Iron supplementation should be prescribed routinely during 4-9 months of age in healthy Thai EBF infants.
缺铁性贫血（IDA）在纯母乳喂养（EBF）的泰国婴儿中很常见。然而，在泰国，尚无针对 EBF 婴儿的补铁指南。本前瞻性开放标签研究旨在评估从 4 月龄开始补充铁剂直至婴儿摄入足够的高铁食物后，9 月龄 EBF 婴儿 IDA 的患病率。47 名健康的 4 月龄 EBF 婴儿每天服用 1mg/kg 硫酸亚铁。计算 6-9 月龄的补充食物记录以获得每日铁摄入量。9 月龄时进行全血细胞计数和铁研究。结果显示，9 月龄 IDA 的患病率为 6.4%。有职业照护者和男婴的铁缺乏症与 IDA 显著相关。食物记录显示，中位数每日铁摄入量低于泰国膳食参考摄入量推荐值。总之，在未开补铁剂的情况下，9 月龄 EBF 婴儿的 IDA 患病率（25.7%）低于背景率，且大多数婴儿的辅食中没有足够的铁。在健康的泰国 EBF 婴儿中，4-9 月龄期间应常规补铁。
