Kintz Pascal, Gheddar Laurie, Pichini Simona, Plebani Mario, Salomone Alberto
X-Pertise Consulting, Mittelhausbergen, France.
Institut de médecine légale, Strasbourg, France.
Clin Chem Lab Med. 2024 Oct 15. doi: 10.1515/cclm-2024-1165.
Clostebol, the 4-chloro derivative of testosterone, available as Over The Counter product in pharmacies and drugstores in several countries, is mostly commercialized as a cream or spray in the form of acetate ester. As other anabolic steroids, clostebol is listed as a prohibited substance by the World Anti-Doping Agency (WADA). Controlled transdermal application of clostebol acetate has been reported to produce detectable amounts of its metabolites in urine, even after a single exposure. Indeed, a low urine concentration can be interpreted as the tail of a drug voluntarily used to enhance performance or a direct consequence of a contamination. The increased number of adverse analytical findings (AAFs) involving clostebol reported in the last years should lead to highlight the need for athletes to be warned against personal and /or accidental use/exposure of dermal preparation containing this doping agent. Further discussion on possible threshold limits and laboratory testing on different matrices (e.g. hair) to better clarify the origin of minimal amounts of clostebol in urines is advisable.
氯睾酮是睾酮的4-氯衍生物，在多个国家的药店和药房作为非处方产品出售，大多以醋酸酯形式制成乳膏或喷雾剂进行商业化销售。与其他合成代谢类固醇一样，氯睾酮被世界反兴奋剂机构（WADA）列为违禁物质。据报道，即使单次使用醋酸氯睾酮经皮控释制剂后，尿液中也会产生可检测到的代谢物。实际上，低尿液浓度可被解释为运动员为提高成绩而主动使用药物的残留，或是受到污染的直接后果。近年来，涉及氯睾酮的不利分析结果（AAF）数量不断增加，这凸显了有必要警告运动员警惕含有这种兴奋剂的皮肤制剂的个人使用和/或意外接触。建议进一步讨论可能的阈值限制，并对不同基质（如毛发）进行实验室检测，以更好地阐明尿液中微量氯睾酮的来源。
