Choi Joo Won, Qiao Yang, Mehta Tej I, Clausen Thomas M, Zhang Y Jonathan, Tsappidi Samuel, Hui Ferdinand K
Department of Neurosciences, UC San Diego School of Medicine, La Jolla, CA, USA.
Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Interv Neuroradiol. 2024 Oct 14:15910199241283513. doi: 10.1177/15910199241283513.
IntroductionWith emerging evidence supporting the clinical efficacy and safety of mechanical thrombectomy (MT) for distal medium vessel occlusions (DMVOs), MT devices specifically designed to navigate through smaller caliber and more delicate tortuous distal cerebrovasculature are required. This study describes our single-center experience using the AXS Vecta 46 intermediate catheter for first-line thromboaspiration of DMVOs.MethodsWe identified all patients who underwent MT using the Vecta 46 for first-line thromboaspiration for primary or secondary DMVOs. We collected baseline clinical data, angiographic and clinical outcomes, as well as procedural complications. The primary outcome in question was the rate of successful recanalization, which was defined as a modified Thrombolysis in Cerebral Infarction score of ≥2b.ResultsWe identified 43 patients who underwent MT using the Vecta 46 catheter for thromboaspiration of 54 DMVOs. Intervened vessels included the M2 (23/54), M3 (19/54), and M4 (6/54) branches of the middle cerebral artery, A2 (1/54), A3 (1/54), and A4 (1/54) branches of the anterior cerebral artery, and P1 (1/54), P2 (1/54), and P4 (1/54) branches of the posterior cerebral artery. The median number of passes for primary DMVOs was 2 (IQR: 1-3) and 1 (IQR: 1-1.25) for secondary DMVOs. The rate of successful recanalization was 100% (18/18) for primary DMVOs and 80.6% (29/36) for secondary DMVOs. First-pass effect (FPE) was noted in 55.6% (30/54) of all primary and secondary DMVO cases. Improved short-term clinical outcomes were observed in both the primary (National Institute of Health Stroke Scale [NIHSS] shift: -5 [IQR: -14.25 to -0.25]) and secondary (NIHSS shift: -5 [IQR: -10 to -2]) DMVO groups. A total of six patients died during their hospitalization, though none were deemed procedural-related.ConclusionsOur study demonstrates the safety and efficacy of the Vecta 46 intermediate catheter for thromboaspiration of both primary and secondary DMVOs, achieving high rates of successful recanalization and FPE.
引言
随着越来越多的证据支持机械取栓术(MT)治疗远端中等血管闭塞(DMVO)的临床疗效和安全性,需要专门设计用于在较小管径和更精细曲折的远端脑血管系统中导航的MT设备。本研究描述了我们使用AXS Vecta 46中间导管对DMVO进行一线血栓抽吸的单中心经验。
方法
我们确定了所有使用Vecta 46进行一线血栓抽吸治疗原发性或继发性DMVO的患者。我们收集了基线临床数据、血管造影和临床结果以及手术并发症。主要关注的结果是成功再通率,其定义为改良的脑梗死溶栓评分≥2b。
结果
我们确定了43例使用Vecta 46导管进行MT以抽吸54处DMVO的患者。介入的血管包括大脑中动脉的M2(23/54)、M3(19/54)和M4(6/54)分支,大脑前动脉的A2(1/54)、A3(1/54)和A4(1/54)分支,以及大脑后动脉的P1(1/54)、P2(1/54)和P4(1/54)分支。原发性DMVO的中位通过次数为2次(四分位间距:1 - 3),继发性DMVO为1次(四分位间距:1 - 1.25)。原发性DMVO的成功再通率为100%(18/18),继发性DMVO为80.6%(29/36)。在所有原发性和继发性DMVO病例中,55.6%(30/54)观察到首次通过效应(FPE)。原发性(美国国立卫生研究院卒中量表[NIHSS]变化:-5[四分位间距:-14.25至-0.25])和继发性(NIHSS变化:-5[四分位间距:-10至-2])DMVO组均观察到短期临床结果改善。共有6例患者在住院期间死亡,但均与手术无关。
结论
我们的研究证明了Vecta 46中间导管对原发性和继发性DMVO进行血栓抽吸的安全性和有效性,实现了高成功再通率和FPE。