Snider Silvia, De Domenico Pierfrancesco, Roncelli Francesca, Bisoglio Andrea, Braga Matteo, Ghelfi Anna, Barzaghi Lina Raffaella, Mura Cinzia, Mortini Pietro, Gagliardi Filippo
Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), I-20132 Milan, Italy.
Department of Neurosurgery, Duke University, Durham, NC 27701, USA.
Oncol Lett. 2024 Sep 30;28(6):576. doi: 10.3892/ol.2024.14709. eCollection 2024 Dec.
Glioblastoma (GBM) is the most common, fast-growing, and aggressive malignant primary CNS tumor, with a survival time of ~15 months despite the use of surgery and adjuvant treatments. In recent years, there has been a growing interest in exploring the potential contribution of hemostasis and platelet activation in GBM biology. The present study assessed the association between the pre-operative coagulation profile [as indicated by prothrombin time (PT) ratio and activated partial thromboplastin time (aPTT) ratio], overall platelets (PLT) count and the mean platelet volume (MPV) with tumoral characteristics and overall survival in patients with isocitrate dehydrogenase-wildtype (IDH-wt) GBM.
胶质母细胞瘤（GBM）是最常见、生长迅速且具有侵袭性的原发性中枢神经系统恶性肿瘤，尽管采用了手术和辅助治疗，其生存时间约为15个月。近年来，人们越来越关注探索止血和血小板激活在GBM生物学中的潜在作用。本研究评估了术前凝血指标[以凝血酶原时间（PT）比值和活化部分凝血活酶时间（aPTT）比值表示]、血小板总数（PLT）和平均血小板体积（MPV）与异柠檬酸脱氢酶野生型（IDH-wt）GBM患者的肿瘤特征及总生存期之间的关联。
