Pliszczak-Król Aleksandra, Rząsa Anna, Gemra Marianna, Król Jarosław, Łuczak Grzegorz, Zyzak Artur, Zalewski Dariusz, Iwaszko-Simonik Alicja, Graczyk Stanisław
Department of Immunology, Pathophysiology and Veterinary Prevention (Pliszczak-Król, Rząsa, Gemra, Łuczak, Zyzak, Iwaszko-Simonik, Graczyk), Division of Veterinary Microbiology, Department of Pathology (Król), Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, PolandDepartment of Genetics, Plant Breeding and Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland (Zalewski)
Department of Immunology, Pathophysiology and Veterinary Prevention (Pliszczak-Król, Rząsa, Gemra, Łuczak, Zyzak, Iwaszko-Simonik, Graczyk), Division of Veterinary Microbiology, Department of Pathology (Król), Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, PolandDepartment of Genetics, Plant Breeding and Seed Production, Faculty of Life Sciences and Technology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland (Zalewski).
J Vet Diagn Invest. 2016 Sep;28(5):561-7. doi: 10.1177/1040638716658928. Epub 2016 Jul 16.
The literature on hemostatic processes in swine is sparse and often fragmentary; hence, we conducted our study to characterize age-related changes in selected parameters of primary and secondary hemostasis in 50 growing pigs between day 2 and week 24 of age. We measured platelet count (PLT), mean platelet volume, platelet-to-large cell ratio, prothrombin time, activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration. Among primary hemostasis parameters, PLT underwent the largest fluctuation with the animals' age, ranging from 340 to 730 × 10(9)/L. However, statistical significance was only detected for 4-week-old piglets compared to 18-week-old animals. Of the secondary hemostasis parameters measured, TT and aPTT were the most changeable. Activated partial thromboplastin time displayed a characteristic biphasic course, being relatively short before week 5 of age (17.8-19.9 s) and then becoming much longer (28.7-52.5 s). The aPTTs measured in animals 6 weeks of age and older were statistically different (p < 0.01) from those in younger piglets. The 2 main components of hemostasis, platelet hemostasis and plasma coagulation, did not develop at the same time. It took much longer for secondary hemostasis to stabilize, whereas platelet parameters were stable early in life.
关于猪止血过程的文献稀少且往往支离破碎；因此，我们开展了本研究，以描述50头生长猪在2日龄至24周龄期间，初级和次级止血选定参数的年龄相关变化。我们测量了血小板计数（PLT）、平均血小板体积、血小板与大细胞比率、凝血酶原时间、活化部分凝血活酶时间（aPTT）、凝血酶时间（TT）和纤维蛋白原浓度。在初级止血参数中，PLT随动物年龄的波动最大，范围为340至730×10⁹/L。然而，与18周龄动物相比，仅在4周龄仔猪中检测到统计学显著性。在所测量的次级止血参数中，TT和aPTT变化最大。活化部分凝血活酶时间呈现出典型的双相过程，在5周龄前相对较短（17.8 - 19.9秒），然后变得长得多（28.7 - 52.5秒）。6周龄及以上动物的aPTT与较年轻仔猪的aPTT在统计学上存在差异（p < 0.01）。止血的两个主要组成部分，血小板止血和血浆凝血，并非同时发育。次级止血稳定所需的时间长得多，而血小板参数在生命早期就已稳定。
