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马来西亚绿藻及其分离出的非极性化合物的防污活性。

Antifouling activity of Malaysian green seaweed and its isolated non-polar compound.

作者信息

Nik Mohd Sukrri Nik Nurhanis Amira, Farizan Ain Farina, Mohd Ramzi Mujahidah, Rawi Nurul Najihah, Abd Rahman Nor Izzati, Bakar Kamariah, Fu Siong Julius Yong, Azemi Ahmad Khusairi, Ismail Noraznawati

机构信息

Institute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Terengganu, Malaysia.

出版信息

Heliyon. 2024 Sep 24;10(19):e38366. doi: 10.1016/j.heliyon.2024.e38366. eCollection 2024 Oct 15.

DOI:10.1016/j.heliyon.2024.e38366
PMID:39397965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11467595/
Abstract

Marine natural products especially seaweeds have gained much attention to combat biofouling. was determined for its antifouling activity and characterized the isolated non-polar metabolite involved. The methanolic crude extract (MCE) of was screened using crystal violet assay against biofilm-forming bacteria and was further tested on laboratory and field tests. Then, it was fractionated and isolated using Liquid-Liquid Fractionation (LLE) and Column Chromatography (CC). The isolated compound was characterized using Liquid Chromatography-Mass Spectrometry (LC-MS), Nuclear Magnetic Resonance (NMR), and Fourier Transform-Infrared Spectroscopy (FTIR). The current study showed that the growth of biofilm produced by was inhibited by MCE at concentrations of 0.0156 mg/mL. The laboratory test indicated UL5% demonstrated a higher bacterial reduction of bacterial colonies with 1.903 × 10 CFU/mL better than blank paint. According to the field test, crude panels of UL5% were successful in reducing the settlement of fouling organisms due to less macrofouler growth compared to blank paint. The isolated compound A4 was identified as hexadecanoic acid (CHO) through NMR with a molecular mass of 256 g/mol detected using LC-MS. The characterization through FTIR obtained functional groups consisting of CH, CH, C=O, and OH. Therefore, produced hexadecanoic acid as one of the promising compounds from the seaweed group as an eco-friendly antifouling agent.

摘要

海洋天然产物尤其是海藻在对抗生物污损方面备受关注。对其抗污活性进行了测定，并对所分离的非极性代谢产物进行了表征。使用结晶紫测定法对[具体名称未给出]的甲醇粗提物（MCE）针对形成生物膜的细菌进行了筛选，并在实验室和现场测试中进一步进行了测试。然后，使用液 - 液分馏（LLE）和柱色谱法（CC）对其进行分馏和分离。使用液相色谱 - 质谱联用（LC - MS）、核磁共振（NMR）和傅里叶变换红外光谱（FTIR）对分离出的化合物进行了表征。当前研究表明，MCE在浓度为0.0156 mg/mL时可抑制[具体名称未给出]产生的生物膜的生长。实验室测试表明，UL5%显示出比空白涂料更高的细菌菌落减少率，细菌菌落数为1.903×10 CFU/mL。根据现场测试，与空白涂料相比，UL5%的粗面板由于较少的大型污损生物生长，成功减少了污损生物的附着。通过NMR鉴定出分离出的化合物A4为十六烷酸（CHO），使用LC - MS检测到其分子量为256 g/mol。通过FTIR表征获得了由CH、CH、C = O和OH组成的官能团。因此，[具体名称未给出]产生的十六烷酸是海藻类中有前景的化合物之一，可作为一种环保型防污剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/8085f64f489c/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/2822477e681f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/39fb40e20e07/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/a0ccc811f6db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/a7d7e1484ff8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/9ddd86f48e26/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/0916be684e5e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/bdb927c76316/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/113b8810eced/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/fb3395d5b9e7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/7b9d6a2b6d99/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/b542686811f7/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/d29803e774e8/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/b01e215d391c/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/46074702f359/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/8085f64f489c/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/2822477e681f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/39fb40e20e07/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/a0ccc811f6db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/a7d7e1484ff8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/9ddd86f48e26/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/0916be684e5e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/bdb927c76316/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/113b8810eced/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/fb3395d5b9e7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/7b9d6a2b6d99/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/b542686811f7/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/d29803e774e8/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/b01e215d391c/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/46074702f359/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/11467595/8085f64f489c/gr15.jpg

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