Zhang YaNan, Wang XiaoYan, Mou Yue, Wang YingZheng, Liu WeiDong, Feng WeiKe, Chen Rong, Zhang MeiZhi, Sun Jing
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250355, China.
College of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, 250355, China.
Heliyon. 2024 Sep 25;10(19):e38431. doi: 10.1016/j.heliyon.2024.e38431. eCollection 2024 Oct 15.
Metastasis is the main cause of death in cancer patients, the lung is one of the most common metastatic organs of malignant solid tumors. Before tumor cells metastasize to the lungs, they interact with immunosuppressive cells, alveolar epithelial cells, and lung fibroblasts to form a pre-metastatic niche. The pre-metastatic niche is a key factor leading to tumor cell metastasis to the lungs. Research has found that traditional Chinese medicine and its components can inhibit the formation of pre-metastatic niche. Therefore, this article reviewed the research progress on the formation of lung pre-metastatic niche and the intervention of traditional Chinese medicine in pulmonary PMN, in order to provide new Chinese medicine prescriptions and research ideas for further clinical prevention and treatment of tumor metastasis to the lung.
转移是癌症患者死亡的主要原因，肺是恶性实体瘤最常见的转移器官之一。在肿瘤细胞转移至肺之前，它们会与免疫抑制细胞、肺泡上皮细胞和肺成纤维细胞相互作用，形成前转移微环境。前转移微环境是导致肿瘤细胞转移至肺的关键因素。研究发现，中药及其成分可抑制前转移微环境的形成。因此，本文综述了肺前转移微环境形成及中药对肺前转移微环境干预的研究进展，以期为进一步临床防治肿瘤肺转移提供新的中药方剂及研究思路。
