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温针灸联合补肾强骨方有效改善骨质疏松症患者的骨代谢。

Warming acupuncture-moxibustion combined with Bushen Qianggu Recipe effectively improves bone metabolism in osteoporosis patients.

作者信息

Zhang Lei, Hu Fang, Li Keqin, Cao Lei, Zhang Jin, Xie Tian, Zhao Min

机构信息

Orthopedic Department, Wuhan Hospital of Traditional Chinese Medicine Wuhan 430000, Hubei, China.

出版信息

Am J Transl Res. 2024 Sep 15;16(9):5106-5113. doi: 10.62347/ECHR4598. eCollection 2024.

Abstract

BACKGROUND

Osteoporosis (OP) increases the risk of fractures in older adults, with no effective treatment options at present.

OBJECTIVES

To analyze the effects of warming acupuncture-moxibustion (WAM) combined with Bushen Qianggu Recipe on bone metabolism, bone mineral density (BMD), and pain intensity in OP patients.

METHODS

This retrospective study involved 103 patients with OP who were admitted to Wuhan Hospital of Traditional Chinese Medicine between July 2021 and December 2023. The control group consisted of 47 cases given WAM and the research group consisted of 56 cases receiving WAM + Bushen Qianggu Recipe (Rehmanniae Radix 15 g, Radix Rehmanniae Preparata 15 g, Poria cocos 10 g, yam 10 g, rhizoma alismatis 10 g, raspberry 10 g, medlar 10 g, Schisandra chinensis 10 g, Semen Cuscutae 10 g, Epimedium 10 g, Polygonatum sibiricum Red. 10 g, Drynaria 10 g, and Eucommia ulmoides 10 g). Bone metabolism markers (procollagen type I N-terminal propeptide (PINP) and bone-specific alkaline phosphatase (B-ALP)), BMD (lumbar vertebrae at L, femoral neck, and distal 1/3 of the radius), pain intensity (visual analog score (VAS)), dysfunction (Oswestry Dysfunction Index), quality of life (Short-Form 36 Item Health Survey (SF-36)), and overall treatment efficacy were analyzed comparatively.

RESULTS

Compared with the baseline (before treatment) and post-treatment levels in the control group, the research group showed a reduction in PINP and B-ALP, an increase in BMD at the lumbar vertebrae L, femoral neck, and distal 1/3 of the radius, and a decrease in VAS and Oswestry Disability Index scores. Additionally, the research group performed better across various dimensions of the SF-36 scale and had a higher overall effective rate.

CONCLUSIONS

WAM combined with Bushen Qianggu Recipe is effective in alleviating pain intensity and improving bone metabolism, BMD, and quality of life in OP patients; therefore it is deserving of clinical promotion.

摘要

背景

骨质疏松症(OP)增加了老年人骨折的风险,目前尚无有效的治疗方法。

目的

分析温针灸(WAM)联合补肾强骨方对OP患者骨代谢、骨密度(BMD)及疼痛强度的影响。

方法

本回顾性研究纳入了2021年7月至2023年12月期间入住武汉市中医医院的103例OP患者。对照组47例给予温针灸治疗,研究组56例接受温针灸 + 补肾强骨方(熟地黄15g、山茱萸15g、茯苓10g、山药10g、泽泻10g、覆盆子10g、枸杞子10g、五味子10g、菟丝子10g、淫羊藿10g、黄精10g、骨碎补10g、杜仲10g)治疗。比较分析骨代谢标志物(I型前胶原N端前肽(PINP)和骨特异性碱性磷酸酶(B-ALP))、骨密度(腰椎L、股骨颈和桡骨远端1/3)、疼痛强度(视觉模拟评分(VAS))、功能障碍(Oswestry功能障碍指数)、生活质量(简明健康状况调查量表(SF-36))及总体治疗效果。

结果

与对照组治疗前及治疗后的基线水平相比,研究组PINP和B-ALP降低,腰椎L、股骨颈和桡骨远端1/3的骨密度增加,VAS和Oswestry功能障碍指数评分降低。此外,研究组在SF-36量表的各个维度上表现更好,总体有效率更高。

结论

温针灸联合补肾强骨方可有效减轻OP患者的疼痛强度,改善骨代谢、骨密度及生活质量;因此值得临床推广。

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The clinician's guide to prevention and treatment of osteoporosis.临床医生骨质疏松症防治指南。
Osteoporos Int. 2022 Oct;33(10):2049-2102. doi: 10.1007/s00198-021-05900-y. Epub 2022 Apr 28.

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