Qi Xiao-Lei, Wu Lin, Guan Ling, Cao Meng-Yu, Zhou Ming, Liu Rong-Rong
Department of Nursing, The Sixth Medical Center of PLA General Hospital Beijing 100048, China.
Department of Neurosurgery, The Sixth Medical Center of PLA General Hospital Beijing 100048, China.
Am J Transl Res. 2024 Sep 15;16(9):4728-4740. doi: 10.62347/PRDN7778. eCollection 2024.
To investigate the pharmacological mechanisms and clinical effects of Traditional Chinese Medicine (TCM) wet compresses on pain, inflammation, and quality of life in patients with soft tissue injuries.
First, the network pharmacology of the active ingredients from TCM wet compresses were identified using the TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform) database (Common monkshood mother root, Two-toothed achyranthes root, Sour orange, Garden balsam stem, Safflower, Ground beetle, Zingiber, Haichow elsholtzia herb). Relevant targets for soft tissue injuries were obtained from GeneCards, revealing 20 key therapeutic targets. Pathway clustering highlighted inflammation-related pathways. Then we conducted clinical investigation by retrospectively analyzing the data of 80 patients with soft tissue injury treated in our hospital from January 2023 to December 2023. The data from healthy subjects who had physical examination in our hospital during the same period served as the control group (n=40). According to the treatment plan, the patients were divided into study group A (n=40, external treatment with Voltaalin ointment), and study group B (n=40, treatment with TCM wet compress). Pain intensity, inflammatory factor levels, and quality of life of the patients between the two groups were compared.
Analysis of TCM wet compresses revealed 86 active ingredients and 259 intersecting targets, with key ingredients including sitogluside, beta-sitosterol, and quercetin. Key targets included IL-6, IL-1B, TNF, CXCL8, and IL10. Clinically, both patient groups showed significant reductions in pain and inflammatory markers, with greater improvements in study group B. In addition, quality of life improved notably post-treatment in study group B.
TCM wet compress patches are effective in reducing pain, modulating inflammation, and improving the quality of life in patients with soft tissue injury. These findings support TCM wet compresses as a promising alternative treatment.
探讨中药湿敷对软组织损伤患者疼痛、炎症及生活质量的药理机制和临床疗效。
首先，利用中药系统药理学数据库与分析平台（TCMSP）数据库（川乌、牛膝、枳壳、凤仙透骨草、红花、土鳖虫、干姜、香薷）鉴定中药湿敷活性成分的网络药理学。从GeneCards获得软组织损伤的相关靶点，共揭示20个关键治疗靶点。通路聚类突出了炎症相关通路。然后，我们通过回顾性分析2023年1月至2023年12月在我院接受治疗的80例软组织损伤患者的数据进行临床研究。同期在我院进行体检的健康受试者的数据作为对照组（n = 40）。根据治疗方案，将患者分为研究组A（n = 40，外用扶他林软膏）和研究组B（n = 40，中药湿敷治疗）。比较两组患者的疼痛强度、炎症因子水平和生活质量。
中药湿敷分析显示86种活性成分和259个交集靶点，关键成分包括谷甾糖苷、β-谷甾醇和槲皮素。关键靶点包括IL-6、IL-1B、TNF、CXCL8和IL10。临床上，两组患者的疼痛和炎症标志物均显著降低，研究组B改善更明显。此外，研究组B治疗后生活质量显著提高。
中药湿敷贴剂可有效减轻软组织损伤患者的疼痛、调节炎症并改善生活质量。这些发现支持中药湿敷作为一种有前景的替代治疗方法。
