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子宫肌瘤所致异常子宫出血:其自然病程及治疗处理的病例报告

Abnormal Uterine Bleeding With Leiomyomas: A Case Report of Its Natural Course and Therapeutic Management.

作者信息

Ahmed Samreen, Ahmed Saba, Gullabzada Mansoor, Gullabzada Uzma, Jobanputra Ketan

机构信息

Medicine, Saint James School of Medicine, Arnos Vale, VCT.

Cardiology, Washington University of Health and Sciences, San Pedro, BLZ.

出版信息

Cureus. 2024 Sep 11;16(9):e69153. doi: 10.7759/cureus.69153. eCollection 2024 Sep.

DOI:10.7759/cureus.69153
PMID:39398676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11467766/
Abstract

Uterine fibroids (UFs), or leiomyomas, are common benign tumors affecting a significant proportion of women by the age of 50 years. While typically non-cancerous, UFs can severely impact the quality of life (QoL) through symptoms such as heavy menstrual bleeding (HMB) and pelvic pain. We report a case of a 45-year-old Hispanic female with a history of hypertension, diabetes, nephrolithiasis, and a solitary kidney, who presented with symptomatic UFs and an ovarian cyst. Despite initial pharmacological treatment with Ortho Micronor and Myfembree, the patient experienced persistent symptoms, prompting surgical intervention. A supracervical hysterectomy, bilateral salpingectomy, lysis of adhesions, and left ovarian cystectomy were performed, resulting in symptom relief and benign postoperative findings. This case report highlights the need for personalized treatment plans and comprehensive patient counseling to manage complex gynecological conditions effectively.

摘要

子宫肌瘤(UFs),即平滑肌瘤,是常见的良性肿瘤,在50岁女性中相当一部分人会受到影响。虽然通常为非癌性,但子宫肌瘤可通过月经过多(HMB)和盆腔疼痛等症状严重影响生活质量(QoL)。我们报告一例45岁西班牙裔女性病例,她有高血压、糖尿病、肾结石病史且为单肾,因出现有症状的子宫肌瘤和卵巢囊肿前来就诊。尽管最初使用炔诺酮和Myfembree进行药物治疗,但患者症状持续,促使进行手术干预。实施了次全子宫切除术、双侧输卵管切除术、粘连松解术和左侧卵巢囊肿切除术,症状得以缓解,术后检查结果为良性。本病例报告强调了制定个性化治疗方案和为患者提供全面咨询以有效管理复杂妇科疾病的必要性。

相似文献

1
Abnormal Uterine Bleeding With Leiomyomas: A Case Report of Its Natural Course and Therapeutic Management.子宫肌瘤所致异常子宫出血:其自然病程及治疗处理的病例报告
Cureus. 2024 Sep 11;16(9):e69153. doi: 10.7759/cureus.69153. eCollection 2024 Sep.
2
The management of uterine leiomyomas.子宫平滑肌瘤的管理
J Obstet Gynaecol Can. 2015 Feb;37(2):157-178. doi: 10.1016/S1701-2163(15)30338-8.
3
The modern management of uterine fibroids-related abnormal uterine bleeding.子宫平滑肌瘤相关异常子宫出血的现代管理。
Fertil Steril. 2024 Jul;122(1):20-30. doi: 10.1016/j.fertnstert.2024.04.041. Epub 2024 May 8.
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Selective progesterone receptor modulators (SPRMs) for uterine fibroids.用于子宫肌瘤的选择性孕激素受体调节剂(SPRMs)
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Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids.瑞戈非尼/雌二醇/醋酸诺孕酯(去氧孕烯):治疗症状性子宫肌瘤的综述。
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Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT.子宫动脉栓塞术与子宫肌瘤剔除术治疗希望避免子宫切除术的绝经前子宫肌瘤妇女:FEMME RCT。
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PLoS One. 2024 Jul 2;19(7):e0306053. doi: 10.1371/journal.pone.0306053. eCollection 2024.
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Translation and validation of the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire for the Brazilian Portuguese language.子宫肌瘤症状与生活质量(UFS-QOL)问卷的巴西葡萄牙语翻译及验证
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The reporting and diagnosis of uterine fibroids in the UK: an observational study.英国子宫肌瘤的报告与诊断:一项观察性研究。
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The management of uterine leiomyomas.子宫平滑肌瘤的管理
J Obstet Gynaecol Can. 2003 May;25(5):396-418; quiz 419-22.

本文引用的文献

1
The modern management of uterine fibroids-related abnormal uterine bleeding.子宫平滑肌瘤相关异常子宫出血的现代管理。
Fertil Steril. 2024 Jul;122(1):20-30. doi: 10.1016/j.fertnstert.2024.04.041. Epub 2024 May 8.
2
Long-term health-related quality of life and symptom severity following hysterectomy, myomectomy, or uterine artery embolization for the treatment of symptomatic uterine fibroids.子宫切除术、子宫肌瘤切除术或子宫动脉栓塞术治疗症状性子宫肌瘤后的长期健康相关生活质量和症状严重程度。
Am J Obstet Gynecol. 2023 Sep;229(3):275.e1-275.e17. doi: 10.1016/j.ajog.2023.05.020. Epub 2023 May 26.
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Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids-A Systematic Review.
子宫肌瘤患者异常子宫出血和不孕的子宫内膜血管生成:系统评价。
Int J Mol Sci. 2023 Apr 10;24(8):7011. doi: 10.3390/ijms24087011.
4
Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids.瑞戈非尼/雌二醇/醋酸诺孕酯(去氧孕烯):治疗症状性子宫肌瘤的综述。
Drugs. 2022 Oct;82(15):1549-1556. doi: 10.1007/s40265-022-01790-4. Epub 2022 Nov 4.
5
From menarche to menopause, heavy menstrual bleeding is the underrated compass in reproductive health.从初潮到绝经,月经过多是生殖健康中被低估的指南针。
Fertil Steril. 2022 Oct;118(4):625-636. doi: 10.1016/j.fertnstert.2022.07.021. Epub 2022 Sep 6.
6
Evaluation and management of abnormal uterine bleeding.异常子宫出血的评估与管理。
Med J Malaysia. 2022 May;77(3):374-383.
7
Conservative Management of Uterine Fibroid-Related Heavy Menstrual Bleeding and Infertility: Time for a Deeper Mechanistic Understanding and an Individualized Approach.子宫肌瘤相关月经过多和不孕症的保守治疗:深入理解机制并采取个体化方法的时候了。
J Clin Med. 2021 Sep 26;10(19):4389. doi: 10.3390/jcm10194389.
8
Physiology of the Endometrium and Regulation of Menstruation.子宫内膜生理学与月经调控。
Physiol Rev. 2020 Jul 1;100(3):1149-1179. doi: 10.1152/physrev.00031.2019. Epub 2020 Feb 7.
9
Abnormal Uterine Bleeding in Premenopausal Women.绝经前妇女的异常子宫出血。
Am Fam Physician. 2019 Apr 1;99(7):435-443.
10
Myoma-associated pain frequency and intensity: a retrospective evaluation of 1548 myoma patients.子宫肌瘤相关疼痛的频率和强度:对1548例子宫肌瘤患者的回顾性评估
Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:137-40. doi: 10.1016/j.ejogrb.2016.02.026. Epub 2016 Feb 21.